Document Detail


The motility of epididymal or testicular spermatozoa does not directly affect IVF/ICSI pregnancy outcomes.
MedLine Citation:
PMID:  16088039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objective was to determine whether the presence of motility in surgically obtained sperm samples improves fertilization and pregnancy rates for patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). This was a retrospective study in a hospital-based infertility center. Sixty-seven couples with a diagnosis of azoospermia or severe oligozoospermia who had undergone a sperm retrieval procedure in conjunction with 100 IVF/ICSI cycles from 1995 to 2004 were evaluated. The impact of sperm motility on fertilization and clinical pregnancy rates was determined. The motile and nonmotile sperm groups differed in the number of mature oocytes retrieved (10.7 +/- 5.8 vs 13.4 +/- 6.0), but fertilization (56.7% vs 59.1%) and embryo cryopreservation rates (35.9% vs 39.3%) were statistically similar. Clinical pregnancy rates did not differ between the motile (38.5%) and nonmotile (31.2%) groups, nor did they differ between obstructive and nonobstructive patients (35.3% vs 26.7%). There was also no statistical difference in pregnancy rates between testicular and epididymal aspiration (35.3% vs 26.7%), although epididymal sperm were significantly more likely to be motile than testicular sperm (100% vs 39.3%, P < .0001). Epididymal aspiration is more likely to produce motile sperm than testicular sperm retrieval. The use of motile sperm from epididymal or testicular samples, however, does not appear to enhance fertilization or clinical pregnancy rates.
Authors:
Kenneth K Moghadam; Reed Nett; Jared C Robins; Michael A Thomas; Sherif G Awadalla; Michael D Scheiber; Daniel B Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of andrology     Volume:  26     ISSN:  0196-3635     ISO Abbreviation:  J. Androl.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-08-09     Completed Date:  2005-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  619-23     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Cincinnati College of Medicine, Cincinnati, OH 45040, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Epididymis / cytology*
Female
Fertilization in Vitro*
Humans
Male
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic*
Sperm Motility*
Testis / cytology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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