| A mother's sacrifice: what is she keeping for herself? | |
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MedLine Citation:
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PMID: 18848886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Individual cells of the budding yeast, Saccharomyces cerevisiae, have a limited life span and undergo a form of senescence termed replicative aging. Replicative life span is defined as the number of daughter cells produced by a yeast mother cell before she ceases dividing. Replicative aging is asymmetric: a mother cell ages but the age of her daughter cells is 'reset' to zero. Thus, one or more senescence factors have been proposed to accumulate asymmetrically between mother and daughter yeast cells and lead to mother-specific replicative senescence once a crucial threshold has been reached. Here we evaluate potential candidates for senescence factors and age-associated phenotypes and discuss potential mechanisms underlying the asymmetry of replicative aging in budding yeast. |
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Authors:
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Kiersten A Henderson; Daniel E Gottschling |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-10-23 |
Journal Detail:
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Title: Current opinion in cell biology Volume: 20 ISSN: 1879-0410 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-02-13 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 723-8 Citation Subset: IM |
Affiliation:
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Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle, WA 98109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division* DNA Replication DNA, Fungal / genetics, metabolism DNA, Ribosomal / genetics, metabolism Gene Expression Regulation, Fungal Genes, Fungal Models, Biological Oxygen / metabolism Phenotype Saccharomyces cerevisiae / cytology*, metabolism Saccharomyces cerevisiae Proteins / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG023779-05/AG/NIA NIH HHS; R01 GM043893-17/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Fungal; 0/DNA, Ribosomal; 0/Saccharomyces cerevisiae Proteins; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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