| The mother's immune system is a balanced threat to the foetus, turning to protection of the neonate. | |
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MedLine Citation:
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PMID: 19046342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunological tolerance by the mother prevents rejection of the foetus, but aberrations may increase risk of abnormalities like spontaneous abortion, or foetal growth restriction. The neonate is normally colonized with mother's gut microflora, mainly composed of protective anaerobes. This least threatening form of microbial colonization of the neonate, is impaired by sectio delivery, but supported by breastfeeding. Mother's transplacental IgG, secretory IgA and other milk components help protect the neonate together with its own slowly expanding immune system. CONCLUSION: The mother's immune system tolerates her foetus via several mechanisms. Failure to do so may cause foetal growth retardation, or spontaneous abortion. The mother and the neonate cooperate in preventing infections in the offspring. |
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Authors:
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Lars A Hanson; Sven Arne Silfverdal |
Publication Detail:
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Type: Journal Article; Review Date: 2008-11-28 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 98 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 221-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Immunology, Göteborg University, Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fetus / immunology* Humans Immunity, Maternally-Acquired / immunology* Infant, Newborn Pregnancy / immunology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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