Document Detail


The most important metabolic risk factors in recurrent urinary stone formers.
MedLine Citation:
PMID:  21656467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate different urinary factors contributing to idiopathic calcium stone disease for determining appropriate medical treatments.
MATERIALS AND METHODS: Two 24-hour urine samples were collected from 106 male recurrent idiopathic calcium stone formers and another 109 randomly selected men as the control group matching for age.
RESULTS: Cases had significantly higher mean urine oxalate, calcium, uric acid, and chloride in comparison with the healthy controls (P < .001). After necessary adjustment, only mean urine levels of oxalate and uric acid were higher in stone formers than those in controls. The mean value of supersaturation for calcium oxalate was significantly higher in patients than the controls (P = .001); whereas supersaturation for calcium phosphate and uric acid did not reach statistical significance (P = .675 and P = .675, respectively). Hyperoxaluria and hypercalciuria were among the most frequent abnormalities. After categorizing urine parameter values into four quartiles, the risk of stone formation was found to increase as the urine calcium, oxalate, uric acid, chloride, and citrate rise. In contrast, the risk of stone formation decreased with the increase of urine potassium.
CONCLUSION: Oxalate seems to play the most important role as urinary stone risk factor in our population followed by calcium and uric acid. In addition to the risk factors, it seems that supersaturation as the sum of all risk factors probably has a high predictive value.
Authors:
Mahmoud Parvin; Nasser Shakhssalim; Abbas Basiri; Amir Hossein Miladipour; Banafsheh Golestan; Peyman Mohammadi Torbati; Mohaddeseh Azadvari; Sanaz Eftekhari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology journal     Volume:  8     ISSN:  1735-546X     ISO Abbreviation:  Urol J     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-10-18     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  101286676     Medline TA:  Urol J     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  99-106     Citation Subset:  IM    
Affiliation:
Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcium / urine
Calcium Oxalate / urine
Calcium Phosphates / urine
Chlorides / urine
Citric Acid / urine
Creatinine / urine
Humans
Male
Middle Aged
Potassium / urine
Recurrence
Risk Factors
Sodium / urine
Uric Acid / urine
Urinary Calculi / etiology,  urine*
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 0/Chlorides; 25454-23-3/Calcium Oxalate; 60-27-5/Creatinine; 69-93-2/Uric Acid; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; 77-92-9/Citric Acid; 97Z1WI3NDX/calcium phosphate

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