Document Detail

A morphometrical study of myocardial disarray associated with right ventricular outflow tract obstruction.
MedLine Citation:
PMID:  6539397     Owner:  NLM     Status:  MEDLINE    
In order to define quantitatively the histological characteristics of the hypertrophied myocardium of the right ventricular outflow tract in patients with congenital heart disease, a light-microscopic study of biopsy specimens obtained from 20 cases with tetralogy of Fallot (TOF) and 14 cases with muscular obstruction of the right ventricular outflow tract ( RVOTO ) was performed using a semi-automatic sampling counter. As the controls, the crista supraventricularis of 11 autopsied cases without cardiac disease were used. The TOF patients were divided into two groups: those with (9 cases) or without (11) a history of hypoxic spells. The myocyte diameter was calculated according to Chalkley 's and Arai 's method. The areas of myocardial fibrosis and myocyte disarray were determined quantitatively by the point count method. Myocardial fibrosis was classified into five types: focal, mild perimysial, severe perimysial, perivascular and plexiform. In the control group, the myocyte diameter and area of fibrosis and disarray tended to increase with age. In the obstructive groups, the myocyte diameter and area of disarray were greater than those of the control in any age group. Myocyte diameter tended to increase with age in all groups, except for the TOF cases with a history of hypoxic spells. The latter also had the largest area of myocardial disarray (25.3%) (p less than 0.01), and a largest area of fibrosis (20.5%) than the TOF cases without spell (14.4%), but severe perimysial fibrosis was observed in only five out of the nine patients with spells. The lack of a relation between the pressure and the presence of an increased area of the myocardial disarray in TOF with spells implies that this myocardial change is brought about by myocardial abnormality accompanied by cardiac malformation.
S Kawai; R Okada; K Kitamura; A Suzuki; S Saito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  48     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-07-09     Completed Date:  1984-07-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  445-56     Citation Subset:  IM    
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MeSH Terms
Cardiomyopathy, Hypertrophic / complications,  pathology*
Child, Preschool
Heart Ventricles / pathology
Myocardium / pathology*
Tetralogy of Fallot / complications,  pathology*

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