Document Detail


The morphometric composition of myelinated fibres by nerve, level and species related to nerve microenvironment and ischaemia.
MedLine Citation:
PMID:  6984385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An extensive morphometric evaluation of the number, density and diameter distribution of myelinated fibres (MFs) of different nerves, of different proximal-distal levels of nerves, and of different species is reported. The methodology used provides reliable estimates of number and size because of the use of optimal histological techniques, semi-thin sections, careful systematic sampling, nonsubjective evaluation of transverse MF profiles using computerized imaging and evaluation of large numbers of MFs and nerves. The non-MF percentage of endoneurial area was also measured as an index of the amount of nerve microenvironment. We have confirmed that the MF composition is quite variable between nerves, between levels of nerves, and between species. In general the density of MFs is lower in the nerves of man than in the nerves of other animals evaluated, in distal than in proximal levels, in old age and in disease. Although increased endoneurial fluid may play a role in resistance to ischaemic block it appears that the intrinsic metabolic properties of the neural tissue itself are most important.
Authors:
P J Dyck; J Karnes; M Sparks; P A Low
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Electroencephalography and clinical neurophysiology. Supplement     Volume:  36     ISSN:  0424-8155     ISO Abbreviation:  Electroencephalogr Clin Neurophysiol Suppl     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375036     Medline TA:  Electroencephalogr Clin Neurophysiol Suppl     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  39-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Humans
Ischemia / pathology*
Myelin Sheath / ultrastructure*
Nervous System / blood supply
Organ Specificity
Peripheral Nerves / ultrastructure*
Peroneal Nerve / ultrastructure
Rana catesbeiana
Rana pipiens
Sciatic Nerve / ultrastructure
Species Specificity
Spinal Cord / ultrastructure
Sural Nerve / ultrastructure
Grant Support
ID/Acronym/Agency:
NS14304/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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