| The morphological, in situ effects of a self-reinforced bioabsorbable polylactide (SR-PLA 96) ureteric stent; an experimental study. | |
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MedLine Citation:
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PMID: 10992415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The present study was done to evaluate the biocompatibility of a new biodegradable double helical spiral self-reinforced poly-L, D-lactide copolymer (L/D ratio 96/4, SR-PLA96) ureteric stent. MATERIALS AND METHODS: In sixteen dogs, the right ureter was cut transversally, sutured and stented with a 50 mm. long SR-PLA 96 stent. In eight dogs, left ureter was similarly operated and stented with a double-J pigtail stent (C-Flex, Cook Urological Inc.), while eight remaining ureters served as plain controls. Urine was analyzed for signs of infection. The dogs were terminated at 6, 12 and 24 weeks postoperatively and the ureters dissected to find persistent SR-PLA 96 particles or local ureteric changes. Histologic samples were taken at three levels of dissected ureters in contact with the stent. RESULTS: C-Flex and SR-PLA 96 materials were well tolerated. Both of these induced only minimal ureteral wall edema, epithelial hyperplasia, epithelial destruction and inflammatory cell reaction. In SR-PLA 96 stented ureters the tissue reaction subsided after the degradation of the device. CONCLUSIONS: SR-PLA 96 spiral stent is regarded highly compatible and SR-PLA 96 might be a suitable material for a partial ureteric stent. Biodegradation of a SR-PLA 96 stent makes stent removal unnecessary. |
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Authors:
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J Lumiaho; A Heino; T Pietiläinen; M Ala-Opas; M Talja; T Välimaa; P Törmälä |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of urology Volume: 164 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-10-05 Completed Date: 2000-10-05 Revised Date: 2006-04-17 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1360-3 Citation Subset: AIM; IM |
Affiliation:
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Departments of Surgery and Pathology, Kuopio University Hospital, Kuopio, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Animals Biocompatible Materials Dogs Foreign-Body Reaction / pathology Lactic Acid* Membranes, Artificial* Polymers* Prosthesis Design Stents* Ureter / pathology |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Membranes, Artificial; 0/Polymers; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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