Document Detail

Of the morphogenes that make a ring, a rod and a sphere in Escherichia coli.
MedLine Citation:
PMID:  17725227     Owner:  NLM     Status:  MEDLINE    
In 1993, William Donachie wrote "The success of molecular genetics in the study of bacterial cell division has been so great that we find ourselves, armed with much greater knowledge of detail, confronted once again with the same naive questions that we set to answer in the first place". Indeed, attempts to answer the apparently simple question of how a bacterial cell divides have led to a wealth of new knowledge, in particular over the past decade and a half. And while some questions have been answered to a great extent since the early reports of isolation of division mutants of Escherichia coli, some key pieces of the puzzle remain elusive. In addition to it being a fundamental process in bacteria that merits investigation in its own right, studying the process of cell division offers an abundance of new targets for the development of new antibacterial compounds that act directly against key division proteins and other components of the cytoskeleton, which are encoded by the morphogenes of E. coli. This review aims to present the reader with a snapshot summary of the key players in E. coli morphogenesis with emphasis on cell division and the rod to sphere transition.
Medhat M Khattar; Issmat I Kassem; Ziad W El-Hajj
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Science progress     Volume:  90     ISSN:  0036-8504     ISO Abbreviation:  Sci Prog     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-29     Completed Date:  2007-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0411361     Medline TA:  Sci Prog     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-72     Citation Subset:  IM    
Department of Biology, American University of Beirut, Lebanon.
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MeSH Terms
Cell Division* / genetics,  physiology
Cytoskeleton* / genetics,  metabolism,  physiology
Escherichia coli* / genetics,  growth & development,  metabolism
Escherichia coli Proteins* / genetics
Reg. No./Substance:
0/Escherichia coli Proteins

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