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A more sensitive pressure-based index to estimate collateral blood supply in case of coronary three-vessel disease.
MedLine Citation:
PMID:  22633139     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
With progressive occlusion of a coronary main artery, some anastomotic vessels are recruited in order to supply blood to the ischemic region. This collateral circulation is an important factor in the preservation of the myocardium until reperfusion of the area at risk. An accurate estimation of collateral flow is crucial in surgical bypass planning as it alters the blood flow distribution in the coronary network and can influence the outcome of a given treatment for a given patient. The evaluation of collateral flow is frequently achieved using an index based on pressure measurements. It is named Collateral Flow Index (CFI) and defined as: (P(w)-P(v))/(P(ao)-P(v)), where P(w) is the pressure distal to the thrombosis, P(ao) the aortic pressure and P(v) the central venous pressure. We propose here another index, that is more sensitive to the P(w) value and could thus describe the role of collateral flow with more precision. We illustrate this idea using some clinical pressure measurements in patients with severe coronary disease (stenoses on the left branches and total occlusion of the right coronary artery).
Authors:
Majid Harmouche; Mahmoud Maasrani; Hervé Corbineau; Jean-Philippe Verhoye; Agnès Drochon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-25
Journal Detail:
Title:  Medical hypotheses     Volume:  -     ISSN:  1532-2777     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Thoracic and Cardiovascular Surgery, Rennes Hospital Center, France; Research Unit INSERM U642, Rennes 1, France.
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