| Imipenem/cilastatin monotherapy as salvage treatment in febrile neutropenic patients. | |
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MedLine Citation:
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PMID: 8957719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Imipenem/cilastatin (I/C) monotherapy was used as salvage treatment in 55 neutropenic patients (58 fever episodes) after treatment failure on first-line antibiotic therapy. Successful antibiotic treatment was defined as eradication of all signs, symptoms and microbiologic evidence of infection on I/C monotherapy alone. Twenty-five out of the 58 episodes (43%) were classified as success, 6 episodes (10%) as initial response but the regimen had to be modified (amphotericin B was added) and 27 episodes (47%) as failures. In episodes with documented infections 9 out of 23 (39%) were classified as success. All patients survived during the first 72 hours after change to I/C therapy. One patient had to discontinue I/C due to a skin rash. In conclusion, the use of a treatment algorithm with I/C monotherapy as second-line treatment was safe and effective. Other antimicrobial agents, most often vancomycin and/or amphotericin B, had to be added in half of the patients. |
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Authors:
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P Engervall; G Günther; P Ljungman; B Lönnqvist; R Hast; G Stiernstedt; M Kalin; S Ringertz; M Björkholm |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of chemotherapy (Florence, Italy) Volume: 8 ISSN: 1120-009X ISO Abbreviation: J Chemother Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-04-02 Completed Date: 1997-04-02 Revised Date: 2009-08-04 |
Medline Journal Info:
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Nlm Unique ID: 8907348 Medline TA: J Chemother Country: ITALY |
Other Details:
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Languages: eng Pagination: 382-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Cilastatin / adverse effects, therapeutic use* Drug Therapy, Combination / adverse effects, therapeutic use* Female Fever / drug therapy*, etiology Humans Imipenem / adverse effects, therapeutic use* Male Middle Aged Neutropenia / complications, drug therapy* Prospective Studies Retreatment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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74431-23-5/Imipenem; 82009-34-5/Cilastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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