Document Detail

The monophasic action potential in clinical cardiology.
MedLine Citation:
PMID:  1810689     Owner:  NLM     Status:  MEDLINE    
For more than 30 years, the monophasic action potential has been used as an experimental tool for the study of myocardial repolarization. With recent improvements in catheter design, the utility of the tool as a means to identify the bases for ventricular arrhythmias in humans has been greatly improved. Abnormalities of repolarization leading to ventricular arrhythmia formation can be identified and specific pharmacologic therapies may be evaluated. Further evaluation of the technique by cardiac electrophysiologists may improve both the diagnosis and the treatment of ventricular arrhythmias dependent upon afterdepolarization formation (acquired and familial long QT syndromes).
E Patterson; W M Jackman; B J Scherlag; R Lazzara
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical cardiology     Volume:  14     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-06-03     Completed Date:  1992-06-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Department of Pharmacology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
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MeSH Terms
Action Potentials / physiology*
Anti-Arrhythmia Agents / therapeutic use
Arrhythmias, Cardiac / physiopathology*,  therapy
Cell Polarity / physiology*
Heart Catheterization
Risk Factors
Ventricular Function*
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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