Document Detail

The monomer covalently closed linear replicative form DNA of Aleutian disease parvovirus is infectious after transfection into permissive cells.
MedLine Citation:
PMID:  8384396     Owner:  NLM     Status:  MEDLINE    
The recently described monomer covalently closed linear replicative form DNA (Mccl RF DNA) of Aleutian disease parvovirus (ADV) is an infectious intermediate of the viral DNA replication cycle. Transfection of highly purified Mccl RF DNA into susceptible feline kidney cells (CCC clone 81 cells) resulted in viral DNA replication, expression of viral proteins and synthesis of infectious progeny virus. Mccl RF DNAs generated under permissive (32 degrees C) or non-permissive (37 degrees C) conditions were shown to be biologically indistinguishable. The accumulation of the Mccl RF DNA form at the non-permissive temperature in vitro strongly resembles that in bone marrow cells of naturally infected mink and may reflect one mechanism contributing to virus persistence of ADV in vivo.
U Truyen; C Schelp; M Löchelt; O R Kaaden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B     Volume:  40     ISSN:  0514-7166     ISO Abbreviation:  Zentralblatt Veterinarmedizin Reihe B     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-20     Completed Date:  1993-04-20     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0331325     Medline TA:  Zentralbl Veterinarmed B     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  66-72     Citation Subset:  IM    
James A. Baker Institute for Animal Health, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
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MeSH Terms
Aleutian Mink Disease Virus / genetics*,  physiology
Cell Line
DNA Replication*
DNA, Viral / physiology*
Virus Replication*
Reg. No./Substance:
0/DNA, Viral

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