| The monolithic fetal pacemaker: prototype lead design for closed thorax deployment. | |
MedLine Citation:
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PMID: 12715839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prenatal sudden cardiac death and hydrops fetalis are often due to complete heart block. However, no pacing modality exists for intrauterine application for fetal bradycardia. A prototype lead for a novel fetal pacemaker has been developed and used in a direct pacing model. It has been demonstrated that the lead can be safely and successfully deployed using a hypochondriac and transdiaphragmatic or subxiphoid approach. Pacing with ventricular capture was evident with the widening of QRS duration from 50.2 +/- 9.8 to 95.1 +/- 12.8 ms (P = 0.0001). Further studies by echocardiogram revealed an increase in the pulse with pacing, confirming pacing. This study documents proof-of-concept for closed thorax over-the-wire deployment of a novel lead design applicable to fetal pacing. By combining the lead design with microcircuitry and a small power source, it is possible to create a monolithic fetal pacemaker system capable of being deployed in utero. |
Authors:
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Joseph Dell'Orfano; Howard A Chou; Daegyun Park; Humair Mirza; Tomasz Stys; Vicki Mahan; Daniel H Zavitz; Boris M Petrikovsky; Marc Ovadia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 26 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-28 Completed Date: 2003-08-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 805-11 Citation Subset: IM |
Affiliation:
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University of Illinois College of Medicine, Chicago, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Pacing, Artificial / methods* Echocardiography Electrocardiography Equipment Design Heart Block / complications, therapy* Hydrops Fetalis / etiology, therapy* Pacemaker, Artificial* Prenatal Care Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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1R43 HL 67520-1/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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