Document Detail


The monolithic fetal pacemaker: prototype lead design for closed thorax deployment.
MedLine Citation:
PMID:  12715839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal sudden cardiac death and hydrops fetalis are often due to complete heart block. However, no pacing modality exists for intrauterine application for fetal bradycardia. A prototype lead for a novel fetal pacemaker has been developed and used in a direct pacing model. It has been demonstrated that the lead can be safely and successfully deployed using a hypochondriac and transdiaphragmatic or subxiphoid approach. Pacing with ventricular capture was evident with the widening of QRS duration from 50.2 +/- 9.8 to 95.1 +/- 12.8 ms (P = 0.0001). Further studies by echocardiogram revealed an increase in the pulse with pacing, confirming pacing. This study documents proof-of-concept for closed thorax over-the-wire deployment of a novel lead design applicable to fetal pacing. By combining the lead design with microcircuitry and a small power source, it is possible to create a monolithic fetal pacemaker system capable of being deployed in utero.
Authors:
Joseph Dell'Orfano; Howard A Chou; Daegyun Park; Humair Mirza; Tomasz Stys; Vicki Mahan; Daniel H Zavitz; Boris M Petrikovsky; Marc Ovadia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  26     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-28     Completed Date:  2003-08-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  IM    
Affiliation:
University of Illinois College of Medicine, Chicago, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Pacing, Artificial / methods*
Echocardiography
Electrocardiography
Equipment Design
Heart Block / complications,  therapy*
Hydrops Fetalis / etiology,  therapy*
Pacemaker, Artificial*
Prenatal Care
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
1R43 HL 67520-1/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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