Document Detail


The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis.
MedLine Citation:
PMID:  15979079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: CD163 is a monocyte-macrophage lineage specific scavenger receptor that mediates the uptake and clearance of haptoglobin-haemoglobin complexes, and soluble CD163 (sCD163) is also present in plasma. As atherosclerosis involves infiltration by monocyte-derived macrophages, we investigated whether sCD163 may act as a marker of coronary atherosclerosis (CAD). METHODS AND RESULTS: Clinical features were identified and plasma was collected from 147 consecutive patients presenting for coronary angiography. Patients were classified as having CAD+, or being free of CAD- haemodynamically significant (>50% luminal diameter) coronary stenoses in one or more major coronary arteries (1, 2 or 3 vessel disease), and sCD163 concentration was measured by ELISA. Plasma sCD163 was non-parametrically distributed, being significantly higher in CAD+ patients (median 2.47 mg/L, 25th-75th percentile, 1.79-3.5mg/L) than in CAD- patients (2.09, 1.31-2.72 mg/L) (p=0.021, Mann-Whitney U-test). LogsCD163 increased significantly with increasing CAD extent (p=0.0036) and was significantly greater in patients with 3 vessel disease than in CAD- patients (p<0.001). Whereas logsCD163 correlated with CAD extent (Spearman r=0.22, p=0.008), logCRP did not, and sCD163 was only weakly correlated with CRP (r=0.19, p=0.039). Importantly, multivariate linear regression identified that sCD163 (p=0.0021) was a significant predictor of CAD extent and was independent of conventional risk factors age (p<0.0001), hypercholesterolemia (p=0.0023), hypertension (p=0.068), and current smoking (p=0.066). CONCLUSIONS: The monocyte-specific marker sCD163 is a novel potential plasma marker of coronary atherosclerotic burden.
Authors:
Lina Panayiota Aristoteli; Holger Jon Møller; Brian Bailey; Søren Kragh Moestrup; Leonard Kritharides
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-23
Journal Detail:
Title:  Atherosclerosis     Volume:  184     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-04-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  342-7     Citation Subset:  IM    
Affiliation:
Clinical Research Group, The Heart Research Institute, Sydney, Australia.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / blood*
Antigens, Differentiation, Myelomonocytic / blood*
Biological Markers / blood
C-Reactive Protein / metabolism
Coronary Angiography
Coronary Artery Disease / blood*,  radiography
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Receptors, Cell Surface / blood*
Receptors, Scavenger / blood*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/Biological Markers; 0/CD163 antigen; 0/Receptors, Cell Surface; 0/Receptors, Scavenger; 9007-41-4/C-Reactive Protein

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