| The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis. | |
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MedLine Citation:
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PMID: 15979079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: CD163 is a monocyte-macrophage lineage specific scavenger receptor that mediates the uptake and clearance of haptoglobin-haemoglobin complexes, and soluble CD163 (sCD163) is also present in plasma. As atherosclerosis involves infiltration by monocyte-derived macrophages, we investigated whether sCD163 may act as a marker of coronary atherosclerosis (CAD). METHODS AND RESULTS: Clinical features were identified and plasma was collected from 147 consecutive patients presenting for coronary angiography. Patients were classified as having CAD+, or being free of CAD- haemodynamically significant (>50% luminal diameter) coronary stenoses in one or more major coronary arteries (1, 2 or 3 vessel disease), and sCD163 concentration was measured by ELISA. Plasma sCD163 was non-parametrically distributed, being significantly higher in CAD+ patients (median 2.47 mg/L, 25th-75th percentile, 1.79-3.5mg/L) than in CAD- patients (2.09, 1.31-2.72 mg/L) (p=0.021, Mann-Whitney U-test). LogsCD163 increased significantly with increasing CAD extent (p=0.0036) and was significantly greater in patients with 3 vessel disease than in CAD- patients (p<0.001). Whereas logsCD163 correlated with CAD extent (Spearman r=0.22, p=0.008), logCRP did not, and sCD163 was only weakly correlated with CRP (r=0.19, p=0.039). Importantly, multivariate linear regression identified that sCD163 (p=0.0021) was a significant predictor of CAD extent and was independent of conventional risk factors age (p<0.0001), hypercholesterolemia (p=0.0023), hypertension (p=0.068), and current smoking (p=0.066). CONCLUSIONS: The monocyte-specific marker sCD163 is a novel potential plasma marker of coronary atherosclerotic burden. |
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Authors:
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Lina Panayiota Aristoteli; Holger Jon Møller; Brian Bailey; Søren Kragh Moestrup; Leonard Kritharides |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-23 |
Journal Detail:
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Title: Atherosclerosis Volume: 184 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-09 Completed Date: 2006-04-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 342-7 Citation Subset: IM |
Affiliation:
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Clinical Research Group, The Heart Research Institute, Sydney, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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blood* Antigens, Differentiation, Myelomonocytic / blood* Biological Markers / blood C-Reactive Protein / metabolism Coronary Angiography Coronary Artery Disease / blood*, radiography Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Male Middle Aged Prognosis Receptors, Cell Surface / blood* Receptors, Scavenger / blood* Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/Biological Markers; 0/CD163 antigen; 0/Receptors, Cell Surface; 0/Receptors, Scavenger; 9007-41-4/C-Reactive Protein |
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