Document Detail


A monoclonal antibody useful for the differential diagnosis between malignant lymphoma and nonhematopoietic neoplasms.
MedLine Citation:
PMID:  6336985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A monoclonal antibody designated as T29/33, which recognizes a major cell surface glycoprotein of hematopoietic cells, was tested as a possible tool to distinguish lymphoma from nonhematopoietic tumors having a similar morphologic appearance by light microscopy. Each of the 40 lymphomas studied by immunofluorescence and/or immunoperoxidase on frozen sections revealed the presence of the corresponding antigen, whereas 110 control tumors of various nonhematopoietic origins were negative. It was concluded that the T29/33 antibody may be of value in resolving the diagnostic problems presented by tumors in which the differential diagnosis is between non-Hodgkin's lymphoma and nonlymphoid tumors.
Authors:
H Battifora; I S Trowbridge
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  51     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-03-17     Completed Date:  1983-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  816-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Animals
Antibodies, Monoclonal / immunology*
Diagnosis, Differential
Fluorescent Antibody Technique
Glycoproteins / immunology
Humans
Immunoenzyme Techniques
Lymphoma / diagnosis*,  immunology,  pathology
Male
Mice
Mice, Inbred BALB C
Neoplasms / diagnosis
Receptors, Antigen, B-Cell / immunology
Grant Support
ID/Acronym/Agency:
1 T32 CA 09308/CA/NCI NIH HHS; 1-R01-CA 25422/CA/NCI NIH HHS; 2-P30-CA-33572/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Glycoproteins; 0/Receptors, Antigen, B-Cell

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