Document Detail


Is the monitoring of anti-Xa activity necessary in pregnant women undergoing thromboprophylaxis?
MedLine Citation:
PMID:  15099863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thromboprophylaxis is increasingly advocated in pregnancy for certain clinical conditions. Low molecular weight heparins offer potential benefit over unfractionated heparins with increased bioavailability and a longer half-life, thus allowing for once daily administration. This study aims to determine if monitoring of anti-Xa activity is necessary in pregnant women undergoing thromboprophylaxis. Twenty-five pregnancies were prospectively followed where either tinzaparin or enoxparin was employed for thromboprophylaxis. Once the anti-Xa levels were in the thromboprophylactic range (0.03-0.5 U/ml) no patient required a change of dose. Frequent monitoring of Anti-Xa levels, once in the thromboprophylactic range, may not be required.
Authors:
Michael P O'Connell; Michael O'Leary; Luke MacKeogh; Karen Murphy; Declan P Keane
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  114     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-21     Completed Date:  2004-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  12-4     Citation Subset:  IM    
Affiliation:
Departments of Obstetrics and Haematology, National Maternity Hospital, Dublin, Ireland. moconnell@coombe.ie
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / therapeutic use*
Diagnostic Tests, Routine
Factor Xa / antagonists & inhibitors*
Female
Heparin, Low-Molecular-Weight / therapeutic use*
Humans
Pregnancy
Pregnancy Complications, Cardiovascular / blood,  prevention & control*
Prenatal Diagnosis*
Prospective Studies
Thrombosis / blood,  prevention & control*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; EC 3.4.21.6/Factor Xa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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