| Is the monitoring of anti-Xa activity necessary in pregnant women undergoing thromboprophylaxis? | |
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MedLine Citation:
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PMID: 15099863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thromboprophylaxis is increasingly advocated in pregnancy for certain clinical conditions. Low molecular weight heparins offer potential benefit over unfractionated heparins with increased bioavailability and a longer half-life, thus allowing for once daily administration. This study aims to determine if monitoring of anti-Xa activity is necessary in pregnant women undergoing thromboprophylaxis. Twenty-five pregnancies were prospectively followed where either tinzaparin or enoxparin was employed for thromboprophylaxis. Once the anti-Xa levels were in the thromboprophylactic range (0.03-0.5 U/ml) no patient required a change of dose. Frequent monitoring of Anti-Xa levels, once in the thromboprophylactic range, may not be required. |
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Authors:
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Michael P O'Connell; Michael O'Leary; Luke MacKeogh; Karen Murphy; Declan P Keane |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 114 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-21 Completed Date: 2004-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 12-4 Citation Subset: IM |
Affiliation:
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Departments of Obstetrics and Haematology, National Maternity Hospital, Dublin, Ireland. moconnell@coombe.ie |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / therapeutic use* Diagnostic Tests, Routine Factor Xa / antagonists & inhibitors* Female Heparin, Low-Molecular-Weight / therapeutic use* Humans Pregnancy Pregnancy Complications, Cardiovascular / blood, prevention & control* Prenatal Diagnosis* Prospective Studies Thrombosis / blood, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; EC 3.4.21.6/Factor Xa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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