| A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer. | |
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MedLine Citation:
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PMID: 11221825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adenomatous polyposis coli (APC) gene is important in the etiology of colon cancer. Although germ-line mutations of this gene rarely occur in the population, less penetrant variants of the gene have been reported. One variant, producing an aspartate to valine change at codon 1822 (D1822V) [corrected] has been previously reported as having an allele frequency of 10%. The purpose of this study was to determine whether this D1822V [corrected] variant of the APC gene is associated with colon cancer and whether its association is influenced by other genetic or environmental factors. We used data collected as part of a multicenter study of 1,585 incident cases of colon cancer and 1,945 age- and sex-matched population-based controls to evaluate genetic, dietary, and environmental associations with the D1822V [corrected] variant of the APC gene. The frequency of the valine/valine allele at codon 1,822 was 22.8% in this population. In the control population, 61.5% were homozygote wild type, 33.3% were heterozygotes, and 5.2% were homozygote variant. Cases were slightly less likely to have the homozygous variant APC genotype than were controls [odds ratio (OR), 0.8; 95% confidence interval (CI), 0.6-1.1]; for those diagnosed after age 65, the homozygous APC variant was associated with reduced risk of colon cancer (OR, 0.6; 95% CI, 0.4-1.0). Assessment of the homozygous APC variant with dietary, genetic, and environmental factors showed that individuals with this genotype were at lower risk if they consumed a low-fat diet (OR, 0.2; 95% CI, 0.1-0.5) relative to those who were homozygous wild type and ate a high-fat diet. This finding was specific to a low-fat diet and was unrelated to other dietary variables. These results suggest that the codon 1,822 variant of the APC gene may have functional significance. Individuals who have the valine/valine variant of this gene may be at reduced risk of colon cancer if they eat a low-fat diet. |
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Authors:
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M L Slattery; W Samowitz; L Ballard; D Schaffer; M Leppert; J D Potter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 61 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-26 Completed Date: 2001-03-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 1000-4 Citation Subset: IM |
Affiliation:
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Department of Family and Preventive Medicine University of Utah, Salt Lake City, 84112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alleles Case-Control Studies Codon Colonic Neoplasms / etiology, genetics* Diet* Dietary Fats / adverse effects* Female Genes, APC Genetic Predisposition to Disease Humans Life Style* Male Middle Aged Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA48998/CA/NCI NIH HHS; CA59045/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/Dietary Fats |
| Comments/Corrections | |
Erratum In:
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Cancer Res 2001 Apr 1;61(7):3222 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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