Document Detail

A molecular spring for vision.
MedLine Citation:
PMID:  15563129     Owner:  NLM     Status:  MEDLINE    
Light absorption by the visual pigment rhodopsin leads to vision via a complex signal transduction pathway that is initiated by the ultrafast and highly efficient photoreaction of its chromophore, the retinal protonated Schiff base (RPSB). Here, we investigate this reaction in real time by means of unrestrained molecular dynamics simulations of the protein in a membrane mimetic environment, treating the chromophore at the density functional theory level. We demonstrate that a highly strained all-trans RPSB is formed starting from the 11-cis configuration (dark state) within approximately 100 fs by a minor rearrangement of the nuclei under preservation of the saltbridge with Glu113 and virtually no deformation of the binding pocket. Hence, the initial step of vision can be understood as the compression of a molecular spring by a minor change of the nuclear coordinates. This spring can then release its strain by altering the protein environment.
Ute F Röhrig; Leonardo Guidoni; Alessandro Laio; Irmgard Frank; Ursula Rothlisberger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  126     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-25     Completed Date:  2005-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15328-9     Citation Subset:  IM    
Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland.
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MeSH Terms
Models, Molecular
Protein Binding
Quantum Theory
Receptors, G-Protein-Coupled / chemistry*,  metabolism
Retinaldehyde / chemistry*,  metabolism
Rhodopsin / chemistry*,  metabolism
Schiff Bases / chemistry,  metabolism
Reg. No./Substance:
0/Receptors, G-Protein-Coupled; 0/Schiff Bases; 116-31-4/Retinaldehyde; 9009-81-8/Rhodopsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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