Document Detail

The molecular physiology of liver regeneration following partial hepatectomy.
MedLine Citation:
PMID:  12654135     Owner:  NLM     Status:  MEDLINE    
The ability of the liver to regenerate after resection has been known for many years. Two reports from Germany in the late 1800s probably mark the introduction of the phenomenon into the scientific literature, but in the early 1900s the first reviews of this subject had appeared in the English literature. Predating these early scientific reports the legends from the Greek mythology described the fate of Prometheus. As punishment for defying Zeus and revealing the secret of fire to man, Prometheus was chained to a rock and each day had part of his liver ripped out by an eagle which, returning the following day, repeated the torture because his liver regenerated itself overnight. Although the speed of regeneration in the Greek legend is somewhat greater than that observed either clinically or in the laboratory, the myth does serve to emphasise the remarkable ability of the liver to repeatedly regenerate following repeated resections. This review aims to summarise the more recent literature concerning the early molecular events accompanying liver regeneration and to integrate this with the existing knowledge of this subject.
David Mangnall; Nigel C Bird; Ali W Majeed
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  23     ISSN:  1478-3223     ISO Abbreviation:  Liver Int.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-09-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  124-38     Citation Subset:  IM    
University Department of Surgical and Anaesthetic Sciences, K Floor, Royal Hallamshire Hospital, Glossop Road S10 2JF, UK.
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MeSH Terms
Cell Transplantation
Hepatocytes / physiology,  transplantation
Liver Diseases / physiopathology,  therapy
Liver Regeneration / physiology*
Molecular Biology*

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