| CD23/FcεRII: molecular multi-tasking. | |
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MedLine Citation:
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PMID: 20831712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets. |
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Authors:
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M Acharya; G Borland; A L Edkins; L M Maclellan; J Matheson; B W Ozanne; W Cushley |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 162 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-10-29 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 12-23 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology. |
Affiliation:
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Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, CR-UK Beatson Institute, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Humans Ligands* Models, Molecular Molecular Sequence Data Protein Binding Protein Structure, Secondary Protein Structure, Tertiary* Receptors, IgE / chemistry*, genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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//Arthritis Research UK; //Biotechnology and Biological Sciences Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Receptors, IgE |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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