| The molecular mechanisms of neuronal apoptosis. | |
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MedLine Citation:
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PMID: 7849526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the past year, apoptosis has been recognized as a process that is perpetually poised to be initiated--often from the cytoplasm rather than from the nucleus--unless it is suppressed by survival factors. Suspected mediators of apoptosis that have recently been investigated include the cysteine protease interleukin-1 beta-converting enzyme, free radicals and cell cycle kinases. Known inhibitors of programmed cell death, such as Bcl-2 and its homologues, have been further studied, and the results suggest that cell death may be regulated by multiple pathways. With the recent identification of the Drosophila gene reaper, which appears to play a role in the initiation of apoptosis, another genetic system for studying cell death has become available. |
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Authors:
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L L Rubin; C L Gatchalian; G Rimon; S F Brooks |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in neurobiology Volume: 4 ISSN: 0959-4388 ISO Abbreviation: Curr. Opin. Neurobiol. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-03-14 Completed Date: 1995-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111376 Medline TA: Curr Opin Neurobiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 696-702 Citation Subset: IM |
Affiliation:
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Eisai London Laboratories, University College London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Caspase 1 Cell Cycle Cell Death Cysteine Endopeptidases / physiology Drosophila / genetics Humans Nerve Degeneration Nervous System Diseases / pathology Neurons / physiology* Proto-Oncogene Proteins / physiology Proto-Oncogene Proteins c-bcl-2 |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.22.36/Caspase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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