| The molecular mechanisms of glucocorticoids-mediated neutrophil survival. | |
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MedLine Citation:
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PMID: 21504070 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids can be problematic as corticosteroids have been shown to promote neutrophil survival which, in turn, accentuates neutrophilic inflammation. In light of such cases, novel targeted medications must be developed that could control neutrophilic inflammation while still maintaining their antibacterial/anti-fungal properties, thus allowing individuals to maintain effective innate immune responses to invading pathogens. The aim of this review is to describe the molecular mechanisms of neutrophil apoptosis and how these pathways are modulated by glucocorticoids. These new findings are of potential clinical value and provide further insight into treatment of neutrophilic inflammation in lung disease. |
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Authors:
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Arash S Saffar; Heather Ashdown; Abdelilah S Gounni |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current drug targets Volume: 12 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 556-62 Citation Subset: IM |
Affiliation:
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Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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