Document Detail

The molecular machinery of myelin gene transcription in Schwann cells.
MedLine Citation:
PMID:  18803322     Owner:  NLM     Status:  MEDLINE    
During late fetal life, Schwann cells in the peripheral nerves singled out by the larger axons will transit through a promyelinating stage before exiting the cell cycle and initiating myelin formation. A network of extra- and intracellular signaling pathways, regulating a transcriptional program of cell differentiation, governs this progression of cellular changes, culminating in a highly differentiated cell. In this review, we focus on the roles of a number of transcription factors not only in myelination, during normal development, but also in demyelination, following nerve trauma. These factors include specification factors involved in early development of Schwann cells from neural crest (Sox10) as well as factors specifically required for transitions into the promyelinating and myelinating stages (Oct6/Scip and Krox20/Egr2). From this description, we can glean the first, still very incomplete, contours of a gene regulatory network that governs myelination and demyelination during development and regeneration.
John Svaren; Dies Meijer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Glia     Volume:  56     ISSN:  1098-1136     ISO Abbreviation:  Glia     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2009-03-05     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1541-51     Citation Subset:  IM    
Department of Comparative Biosciences, School of Veterinary Medicine and Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
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MeSH Terms
Cell Differentiation / genetics
Gene Expression Regulation, Developmental / genetics*
Myelin Sheath / genetics*,  metabolism
Nerve Fibers, Myelinated / metabolism*,  ultrastructure
Peripheral Nervous System / cytology,  embryology*,  metabolism
Schwann Cells / metabolism*,  ultrastructure
Signal Transduction / genetics
Transcription Factors / genetics,  metabolism
Transcription, Genetic / genetics*
Grant Support
Reg. No./Substance:
0/Transcription Factors

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