Document Detail

The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae.
MedLine Citation:
PMID:  18427108     Owner:  NLM     Status:  MEDLINE    
The mosquito Anopheles gambiae is the principal Afrotropical vector for human malaria. A central component of its vectorial capacity is the ability to maintain sufficient populations of adults. During both adult and preadult (larval) stages, the mosquitoes depend on the ability to recognize and respond to chemical cues that mediate feeding and survival. In this study, we used a behavioral assay to identify a range of odorant-specific responses of An. gambiae larvae that are dependent on the integrity of the larval antennae. Parallel molecular analyses have identified a subset of the An. gambiae odorant receptors (AgOrs) that are localized to discrete neurons within the larval antennae and facilitate odor-evoked responses in Xenopus oocytes that are consistent with the larval behavioral spectrum. These studies shed light on chemosensory-driven behaviors and represent molecular and cellular characterization of olfactory processes in mosquito larvae. These advances may ultimately enhance the development of vector control strategies, targeting olfactory pathways in larval-stage mosquitoes to reduce the catastrophic effects of malaria and other diseases.
Yuanfeng Xia; Guirong Wang; Daniela Buscariollo; R Jason Pitts; Heidi Wenger; Laurence J Zwiebel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-04-21
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  105     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-30     Completed Date:  2008-05-22     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6433-8     Citation Subset:  IM    
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MeSH Terms
Animal Structures / drug effects,  ultrastructure
Anopheles gambiae / drug effects,  physiology*,  ultrastructure
Behavior, Animal* / drug effects
Gene Expression Regulation / drug effects
Larva / drug effects,  ultrastructure
Neurons, Afferent / drug effects,  metabolism
Olfactory Pathways / drug effects,  physiology*
Organic Chemicals / pharmacology
Receptors, Odorant / genetics,  metabolism
Grant Support
Reg. No./Substance:
0/Organic Chemicals; 0/Receptors, Odorant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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