Document Detail

The molecular basis of skeletal metastases.
MedLine Citation:
PMID:  14600589     Owner:  NLM     Status:  MEDLINE    
Metastasis is the culmination of numerous highly regulated sequences of steps that results in the proliferation and migration of cells from the primary site to a distant location. The biologic consequence of skeletal metastasis is focal bone sclerosis or osteolysis that leads to pain, pathologic fracture, and biochemical derangement. The difficulty in determining a point of control for clinical application has been because of the numerous systems, substrates, ligands, receptors, factors, and pathways that exist. These may be grouped into functional mechanisms identifiable by their relevance to the metastatic process. These include cell-cell or cell-matrix adhesion, invasion and migration, interactions with endothelial cells, growth factor regulation, proteolysis, and stimulation of differentiated osteoblast and osteoclast function. The challenge for cancer therapy will be to identify means to prevent metastasis or reduce its effect once it occurred. This review examines recent advances in the study of molecular processes of metastasis, which have identified potential sites and substrates for targeting with novel therapies and agents.
Peter F M Choong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2003-12-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S19-31     Citation Subset:  AIM; IM    
Department of Orthopaedics, The University of Melbourne, St Vincent's Hospital, Melbourne, Australia.
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MeSH Terms
Bone Neoplasms / metabolism,  pathology,  physiopathology*,  secondary*
Cadherins / physiology
Cell Adhesion Molecules / physiology
Extracellular Matrix / physiology
Integrins / physiology
Neoplasm Metastasis / physiopathology*
Osteoblasts / pathology
Osteoclasts / pathology
Receptors, Cell Surface / physiology
Receptors, Urokinase Plasminogen Activator
Vascular Cell Adhesion Molecule-1 / physiology
Reg. No./Substance:
0/Cadherins; 0/Cell Adhesion Molecules; 0/Integrins; 0/PLAUR protein, human; 0/Receptors, Cell Surface; 0/Receptors, Urokinase Plasminogen Activator; 0/Vascular Cell Adhesion Molecule-1

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