Document Detail


The molecular basis of pediatric hypertension.
MedLine Citation:
PMID:  17027621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure, the product of cardiac output and peripheral vascular resistance, follows a circadian rhythm and is altered by a host of circulating and local substances and by many physiologic events. The number of genes, signaling pathways, and systems involved in blood pressure regulation is enormous, and dissecting those factors that are most important in hypertension has proven challenging. This article discusses molecular mechanisms of hypertension in several conditions in which mutations in a single gene give rise to hypertension and then considers the contribution of these and other genes to essential hypertension.
Authors:
Julie R Ingelfinger
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric clinics of North America     Volume:  53     ISSN:  0031-3955     ISO Abbreviation:  Pediatr. Clin. North Am.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-09     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401126     Medline TA:  Pediatr Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1011-28, x-xi     Citation Subset:  AIM; IM    
Affiliation:
Pediatric Nephrology, Yawkey 6C, MassGeneral Hospital for Children at Massachusetts General Hospital, and Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. jingelfinger@partners.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Child
Disease Models, Animal
Humans
Hypertension / classification,  genetics*,  physiopathology
Molecular Biology / methods
Mutation

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