| The molecular basis of host adaptation in cactophilic Drosophila: molecular evolution of a glutathione S-transferase gene (GstD1) in Drosophila mojavensis. | |
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MedLine Citation:
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PMID: 18245335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Drosophila mojavensis is a cactophilic fly endemic to the northwestern deserts of North America. This species includes four genetically isolated cactus host races each individually specializing on the necrotic tissues of a different cactus species. The necrosis of each cactus species provides the resident D. mojavensis populations with a distinct chemical environment. A previous investigation of the role of transcriptional variation in the adaptation of D. mojavensis to its hosts produced a set of candidate loci that are differentially expressed in response to host shifts, and among them was glutathione S-transferase D1 (GstD1). In both D. melanogaster and Anopheles gambiae, GstD1 has been implicated in the resistance of these species to the insecticide dichloro-diphenyl-trichloroethane (DDT). The pattern of sequence variation of the GstD1 locus from all four D. mojavensis populations, D. arizonae (sister species), and D. navojoa (outgroup) has been examined. The data suggest that in two populations of D. mojavensis GstD1 has gone through a period of adaptive amino acid evolution. Further analyses indicate that of the seven amino acid fixations that occurred in the D. mojavensis lineage, two of them occur in the active site pocket, potentially having a significant effect on substrate specificity and in the adaptation to alternative cactus hosts. |
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Authors:
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Luciano M Matzkin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-02-01 |
Journal Detail:
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Title: Genetics Volume: 178 ISSN: 0016-6731 ISO Abbreviation: Genetics Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-21 Completed Date: 2008-06-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374636 Medline TA: Genetics Country: United States |
Other Details:
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Languages: eng Pagination: 1073-83 Citation Subset: IM |
Affiliation:
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Department of Ecology and Evolutionary Biology and Center for Insect Science, University of Arizona, Tucson, Arizona 85721, USA. lmatzkin@email.arizona.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/EU079380; EU079381; EU079382; EU079383; EU079384; EU079385; EU079386; EU079387; EU079388; EU079389; EU079390; EU079391; EU079392; EU079393; EU079394; EU079395; EU079396; EU079397; EU079398; EU079399; EU079400; EU079401; EU079402; EU079403; EU079404; EU079405; EU079406; EU079407; EU079408; EU079409; EU079410; EU079411; EU079412; EU079413; EU079414; EU079415; EU079416; EU079417; EU079418; EU079419; EU079420; EU079421; EU079422; EU079423; EU079424; EU079425; EU079426; EU079427; EU079428; EU079429; EU079430; EU079431; EU079432; EU079433; EU079434; EU079435; EU079436; EU079437; EU079438; EU079439; EU079440; EU079441; EU079442; EU079443; EU079444; EU079445; EU079446; EU079447; EU079448; EU079449; EU079450; EU079451; EU079452; EU079453; EU079454; EU079455; EU079456; EU079457; EU079458; EU079459; EU079460; EU079461; EU079462; EU079463; EU079464; EU079465; EU079466; EU079467; EU079468; EU079469; EU079470; EU079471 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Animals Desert Climate Drosophila / classification, enzymology*, genetics* Drosophila Proteins / genetics Evolution, Molecular* Genetic Variation Geography Glutathione Transferase / genetics* Mexico Molecular Sequence Data Phylogeny United States |
| Grant Support | |
ID/Acronym/Agency:
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2K12 G000798-06//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; EC 2.5.1.18/Glutathione Transferase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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