Document Detail


The molecular basis for attractive salt-taste coding in Drosophila.
MedLine Citation:
PMID:  23766326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Below a certain level, table salt (NaCl) is beneficial for animals, whereas excessive salt is harmful. However, it remains unclear how low- and high-salt taste perceptions are differentially encoded. We identified a salt-taste coding mechanism in Drosophila melanogaster. Flies use distinct types of gustatory receptor neurons (GRNs) to respond to different concentrations of salt. We demonstrated that a member of the newly discovered ionotropic glutamate receptor (IR) family, IR76b, functioned in the detection of low salt and was a Na(+) channel. The loss of IR76b selectively impaired the attractive pathway, leaving salt-aversive GRNs unaffected. Consequently, low salt became aversive. Our work demonstrated that the opposing behavioral responses to low and high salt were determined largely by an elegant bimodal switch system operating in GRNs.
Authors:
Yali V Zhang; Jinfei Ni; Craig Montell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  340     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-14     Completed Date:  2013-06-27     Revised Date:  2014-07-13    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1334-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal
Chemoreceptor Cells / physiology
Drosophila Proteins / genetics,  physiology*
Drosophila melanogaster / physiology*
Gene Deletion
Receptors, Glutamate
Receptors, Ionotropic Glutamate / genetics,  physiology*
Sensilla / physiology
Sodium Channels / genetics,  physiology*
Sodium Chloride*
Taste Perception / genetics,  physiology*
Grant Support
ID/Acronym/Agency:
DC007864/DC/NIDCD NIH HHS; R01 DC007864/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/IR76b protein, Drosophila; 0/Receptors, Glutamate; 0/Receptors, Ionotropic Glutamate; 0/Sodium Channels; 7647-14-5/Sodium Chloride
Comments/Corrections
Comment In:
Science. 2013 Jun 14;340(6138):1295-7   [PMID:  23766319 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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