Document Detail

The molecular basis of T cell acute lymphoblastic leukemia.
MedLine Citation:
PMID:  23023710     Owner:  NLM     Status:  MEDLINE    
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.
Pieter Van Vlierberghe; Adolfo Ferrando
Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3398-406     Citation Subset:  AIM; IM    
Institute for Cancer Genetics, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA.
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MeSH Terms
Cell Cycle Proteins / genetics,  physiology
Cell Lineage
Cell Transformation, Neoplastic / genetics
Chromatin Assembly and Disassembly / genetics,  physiology
Cyclin-Dependent Kinase Inhibitor p16 / physiology
Genes, p16
Hematopoietic Stem Cells / pathology
Homeodomain Proteins / genetics,  physiology
Molecular Targeted Therapy
Neoplasm Proteins / genetics,  physiology*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / classification,  etiology,  genetics*
Receptors, Notch / physiology
Signal Transduction / genetics,  physiology
T-Lymphocytes / pathology
Transcription Factors / physiology
Tumor Suppressor Proteins / genetics,  physiology
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/Homeodomain Proteins; 0/Neoplasm Proteins; 0/Receptors, Notch; 0/Transcription Factors; 0/Tumor Suppressor Proteins

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