Document Detail

The modulatory effects of connexin 43 on cell death/survival beyond cell coupling.
MedLine Citation:
PMID:  17462722     Owner:  NLM     Status:  MEDLINE    
Connexins form a diverse and ubiquitous family of integral membrane proteins. Characteristically, connexins are assembled into intercellular channels that aggregate into discrete cell-cell contact areas termed gap junctions (GJ), allowing intercellular chemical communication, and are essential for propagation of electrical impulses in excitable tissues, including, prominently, myocardium, where connexin 43 (Cx43) is the most important isoform. Previous studies have shown that GJ-mediated communication has an important role in the cellular response to stress or ischemia. However, recent evidence suggests that connexins, and in particular Cx43, may have additional effects that may be important in cell death and survival by mechanisms independent of cell to cell communication. Connexin hemichannels, located at the plasma membrane, may be important in paracrine signaling that could influence intracellular calcium and cell survival by releasing intracellular mediators as ATP, NAD(+), or glutamate. In addition, recent studies have shown the presence of connexins in cell structures other than the plasma membrane, including the cell nucleus, where it has been suggested that Cx43 influences cell growth and differentiation. In addition, translocation of Cx43 to mitochondria appears to be important for certain forms of cardioprotection. These findings open a new field of research of previously unsuspected roles of Cx43 intracellular signaling.
Antonio Rodríguez-Sinovas; Alberto Cabestrero; Diego López; Iratxe Torre; Miriam Morente; Arancha Abellán; Elisabet Miró; Marisol Ruiz-Meana; David García-Dorado
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-03-14
Journal Detail:
Title:  Progress in biophysics and molecular biology     Volume:  94     ISSN:  0079-6107     ISO Abbreviation:  Prog. Biophys. Mol. Biol.     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401233     Medline TA:  Prog Biophys Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-32     Citation Subset:  IM    
Laboratorio de Cardiología Experimental, Servicio de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain.
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MeSH Terms
Adaptation, Physiological / physiology*
Apoptosis / physiology*
Cell Communication / physiology
Cell Nucleus / physiology*
Cell Survival / physiology*
Gap Junctions / physiology*
Mitochondria / physiology*
Models, Biological*
Oxidative Stress / physiology

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