Document Detail


Is the modulatory effect of pregnancy in multiple sclerosis associated with changes in blood apoptotic molecules?
MedLine Citation:
PMID:  20695850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We examined whether the modulatory effect of pregnancy on multiple sclerosis (MS) is associated with changes in the apoptotic molecules in sera.
SUBJECTS AND METHODS: The serum levels of tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), sFas, Fas ligand (sFasL) and macrophage migration inhibitory factor were analyzed from 19 MS patients and 14 controls during late pregnancy and post-partum. The obtained results were related to disease activity and the progression of MS.
RESULTS: Disease activity decreased during pregnancy. The levels of sTRAIL and sFasL increased from late pregnancy to post-partum situation in both MS patients and controls, but in MS patients the changes in the levels of sTRAIL from late pregnancy to post-partum were smaller than in controls.
CONCLUSIONS: Post-partum upregulation of TRAIL and FasL seems to be caused by physiologic reactivation of the mother's immune system after pregnancy. An increased risk of relapses in MS post-partum may be associated with changes in the immunomodulatory potential of these apoptotic molecules.
Authors:
S Rinta; L Airas; I Elovaara
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  122     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  168-74     Citation Subset:  IM    
Affiliation:
Neuroimmunology Unit, Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD95 / blood*
Cell Migration Assays, Macrophage / methods
Cytokines / blood
Fas Ligand Protein / blood*
Female
Humans
Multiple Sclerosis / blood*
Postpartum Period / blood
Pregnancy
TNF-Related Apoptosis-Inducing Ligand / blood*
Up-Regulation / physiology*
Chemical
Reg. No./Substance:
0/Antigens, CD95; 0/Cytokines; 0/Fas Ligand Protein; 0/TNF-Related Apoptosis-Inducing Ligand

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