Document Detail


The modulation of skin irritation.
MedLine Citation:
PMID:  7867323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Irritant contact dermatitis (ICD) is a multifactorial disease, the onset and modulation of which depend on both endogenous and exogenous factors. Among the former, age, race, site, sex and history of dermatitis may all be important. Such variables can now readily be quantified by objective noninvasive techniques, such as measurement of transepidermal water loss (TEWL). Moreover, effects of irritants on the epidermis are related to the particular chemical properties of each molecule, contributing further to clinical heterogeneity. Release of cytokines and mediators may be initiated by a number of cells, including living keratinocytes and those of the stratum corneum, thus modulating inflammation and repair. Furthermore, differences in mechanisms of inflammation between acute and chronic ICD may exist, the former being characterized predominantly by inflammation, the latter by hyperproliferation and transient hyperkeratosis. These findings may explain the complexity and difficulty of investigating ICD. Better understanding and quantification of these mechanisms may lead to identification of high-risk individuals and more effective prevention and treatment.
Authors:
E Berardesca; F Distante
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Contact dermatitis     Volume:  31     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-28     Completed Date:  1995-03-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  281-7     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Pavia, IRCCS Policlinico S. Matteo, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Chronic Disease
Cytokines / immunology
Dermatitis, Irritant / etiology,  immunology,  pathology,  physiopathology*
Humans
Irritants / chemistry
Risk Factors
Water Loss, Insensible / physiology
Chemical
Reg. No./Substance:
0/Cytokines; 0/Irritants

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