| Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs? | |
| | |
MedLine Citation:
|
PMID: 20398699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Melatonin, the darkness hormone, synchronizes several physiological functions to light/dark cycle. Besides the awake/sleep cycle that is intuitively linked to day/night, daily variations in memory acquisition and innate or acquired immune responses are some of the major activities linked to melatonin rhythm. The daily variation of these complex processes is due to changes in specific mechanisms. In the last years we focused on the influence of melatonin on the expression and function of nicotinic acetylcholine receptors (nAChRs). Melatonin, either "in vivo" or "in vitro", increases, in a selective manner, the efficiency of alpha-bungarotoxin (alpha-BTX)-sensitive nAChRs. Melatonin's effect on receptors located in rat sympathetic nerve terminals, cerebellum, skeletal muscle and chick retina, was tested. We observed that melatonin is essential for the development of alpha-BTX-sensitive nAChRs, and important for receptor maintenance in aging models. Taking into account that both melatonin and alpha-7 nAChRs (one of the subtypes sensitive to alpha-BTX) are involved in the development of Alzheimer's disease, here we discuss the possibility of a therapeutic strategy focused on both melatonin replacement and its potential association with cholinergic drugs. |
| | |
Authors:
|
Regina P Markus; Claudia L M Silva; Daiane Gil Franco; Eduardo Mortani Barbosa; Zulma S Ferreira |
Related Documents
:
|
18331729 - Role of acetylcholine receptors in proliferation and differentiation of p19 embryonal c... 11825589 - Low-affinity ca(2+) and ba(2+) binding sites in the pore of alpha7 nicotinic acetylchol... 15522249 - High-affinity nicotinic acetylcholine receptors are required for antidepressant effects... 12411519 - Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcho... 10082289 - Immunolocalization of alpha4 and alpha7 subunits of nicotinic receptor in rat cochlear ... 15213309 - A single point mutation confers properties of the muscle-type nicotinic acetylcholine r... 21573419 - Melatonin modulation of estrogen-receptor expression in mcf-7 human breast-cancer cells. 18248609 - A role for p53 in the regulation of lysosomal permeability by delta 9-tetrahydrocannabi... 2883609 - Denervation supersensitivity of striatal d2 dopamine receptors is restricted to the ven... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-14 |
Journal Detail:
|
Title: Pharmacology & therapeutics Volume: 126 ISSN: 1879-016X ISO Abbreviation: Pharmacol. Ther. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-21 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905840 Medline TA: Pharmacol Ther Country: England |
Other Details:
|
Languages: eng Pagination: 251-62 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, Universidade de São Paulo, Brazil. rpmarkus@usp.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
drug therapy,
metabolism Animals Cholinergic Agents / administration & dosage* Drug Therapy, Combination Humans Melatonin / administration & dosage*, physiology* Receptors, Nicotinic / physiology* Signal Transduction / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Cholinergic Agents; 0/Receptors, Nicotinic; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardioplegia and Cardiac Surgery: Pharmacological arrest and cardioprotection during global ischemia...
Next Document: A novel microsurgical nerve implantation technique preserving outer nerve layers.