Document Detail

The modulation of lifespan by perceptual systems.
MedLine Citation:
PMID:  19686214     Owner:  NLM     Status:  MEDLINE    
Could the mere perception of food availability reverse the beneficial effects of diet restriction, which robustly increases lifespan and reduces aging-related disease in many species? We had noted from previous work in Drosophila that the effects of dietary restriction were fast acting, completely reversible, and largely independent of the energetic content of the food. Indeed, some characteristic of the diet seemed to be "sensed" by the flies independent of their tendency to eat it. We quickly realized that the Drosophila olfactory system, with its well-understood architecture and associated set of genetic tools, was the ideal model to test our hypothesis. Subsequent work resulted in the identification of particular odorants and populations of sensory neurons with potent effects on lifespan, obesity, and metabolism.
Scott D Pletcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1170     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-09-25     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-7     Citation Subset:  IM    
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MeSH Terms
Drosophila melanogaster / physiology*
Longevity / physiology*
Olfactory Perception*
Taste Perception*
Grant Support
R01 AG023166/AG/NIA NIH HHS; R01 AG023166-01A1/AG/NIA NIH HHS; R01 AG023166-02/AG/NIA NIH HHS; R01 AG023166-03/AG/NIA NIH HHS; R01 AG023166-04/AG/NIA NIH HHS; R01 AG023166-05/AG/NIA NIH HHS; R01 AG030593/AG/NIA NIH HHS; R01 AG030593-01/AG/NIA NIH HHS; R01 AG030593-01S1/AG/NIA NIH HHS; R01 AG030593-02/AG/NIA NIH HHS; R01 AG030593-03/AG/NIA NIH HHS

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