| The modifying effects of green tea polyphenols on acute colitis and inflammation-associated colon carcinogenesis in male ICR mice. | |
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MedLine Citation:
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PMID: 20108331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen species (ROS) have been implicated as mediators of intestinal inflammation and carcinogenesis. Although green tea polyphenols (GTP) have anticancer property as antioxidants they also generate ROS in vitro. In this study, we investigated the modifying effects of GTP on dextran sulfate sodium (DSS)-induced acute colitis and on 1,2-dimethylhydrazine (DMH) and DSS-induced colon carcinogenesis in male ICR mice. At sacrifice after 6 days, the colon shortening induced by 2% DSS was unchanged by 0.1% and 0.25% GTP, but increased by 0.5% and 1% GTP-containing diet. The expression of interleukin-1beta and macrophage-migration inhibitory factor in the DSS + 0.1% GTP group were lower than the DSS alone group, whereas the expression levels were increased in the DSS + 0.5% GTP and DSS + 1% GTP groups when compared with the DSS alone group. In a subsequent experiment to determine the effects of 0.01-1% GTP on inflammation-associated colon carcinogenesis induced by DMH/DSS, 0.5 and 1% doses of GTP failed to prevent the development of multiple colon tumors, rather, they tended to increase it. Our results thus indicate that the modifying effects of GTP on DSS-induced acute colitis and DMH/DSS-induced colon carcinogenesis depends upon its dosage and the expression of proinflammatory cytokines. |
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Authors:
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Mihye Kim; Akira Murakami; Shingo Miyamoto; Takuji Tanaka; Hajime Ohigashi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 36 ISSN: 1872-8081 ISO Abbreviation: Biofactors Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-02-11 Completed Date: 2010-04-22 Revised Date: 2010-12-20 |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
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Languages: eng Pagination: 43-51 Citation Subset: IM |
Affiliation:
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Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1,2-Dimethylhydrazine Animals Colitis / chemically induced, complications Colonic Neoplasms / chemically induced, prevention & control* Dextran Sulfate Flavonoids / therapeutic use* Male Mice Mice, Inbred ICR Phenols / therapeutic use* Tea |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Phenols; 0/Tea; 0/polyphenols; 540-73-8/1,2-Dimethylhydrazine; 9042-14-2/Dextran Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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