Document Detail


A modified technique for tail cuff pressure measurement in unrestrained conscious rats.
MedLine Citation:
PMID:  12218357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In physiological experiments, it is essential to measure arterial pressure (AP) and heart rate (HR) in animals. Tail cuff pressure (TCP) measurement using photoelectric volume oscillometry has been commonly used. We designed a new technique for continuous measurement of AP and HR in conscious, unrestrained rats. This is based on the observation that fixation of the rat's tail with tape keeps the animal in position without struggling. The animal is free to move its body. To test the accuracy of this new technique, Sprague-Dawley rats underwent four AP and HR measurement techniques. These included a new unrestrained method (UR), which was compared to the following three methods: traditional restrained TCP method with restrainer, direct monitoring of AP and HR with femoral artery catheterization and a combination of photoelectric volume oscillometry (with body heating to 37 degrees C) and femoral arterial recording. The results show that the modified UR measurement provides accurate data on AP and HR. This method obtains a lower value of HR and similar mean AP when compared to direct monitoring from femoral arterial catheterization. Accordingly, the modified unrestrained TCP measurement can be used in conscious rats as a noninvasive method.
Authors:
Ru Ping Lee; David Wang; Nien Tsung Lin; Yi Wei Chou; Hsing I Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical science     Volume:  9     ISSN:  1021-7770     ISO Abbreviation:  J. Biomed. Sci.     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-09-09     Completed Date:  2003-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421567     Medline TA:  J Biomed Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  424-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 National Science Council, ROC and S. Karger AG, Basel
Affiliation:
Institute of Medical Sciences, Cheng Hsin General Hospital, Hualien, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure Determination / methods*
Heart Rate*
Male
Rats
Rats, Sprague-Dawley
Tail / blood supply*

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