| A modified technique of delayed primary closure using a povidone iodine wick: influence on wound healing in an experimental model. | |
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MedLine Citation:
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PMID: 8244649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a modified technique of delayed primary wound closure using a wound wick. A rodent model was used to determine its influence on healing. After loose primary closure of two paravertebral incisions on the dorsum of male rats, a 10 cm length of ribbon gauze, soaked in either saline or 1% povidone-iodine, was inserted into the right sided wound. Wicks were soaked daily with the same solution until removal on the third post-operative day. The inclusion of a wick soaked in saline had an early transient effect on healing. A more prolonged impairment of healing was demonstrated in povidone-iodine wicked wounds and their respective controls. These data suggest that povidone-iodine impaired healing not only in the wicked wound, but also inhibited healing in the adjacent unwicked wound which was not directly exposed to the antiseptic. The observed delay in healing in povidone-iodine wicked wounds must however be balanced against its beneficial effect on wound infection rates. We suggest that further evaluation of this method of closure in contaminated wounds is warranted. |
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Authors:
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R G Molloy; M P Brady |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Irish journal of medical science Volume: 162 ISSN: 0021-1265 ISO Abbreviation: Ir J Med Sci Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-12-30 Completed Date: 1993-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806864 Medline TA: Ir J Med Sci Country: IRELAND |
Other Details:
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Languages: eng Pagination: 297-300 Citation Subset: IM |
Affiliation:
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University Department of Surgery, Regional Hospital, Cork, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Male Models, Biological Postoperative Care* Povidone-Iodine / pharmacology*, therapeutic use Rats Rats, Sprague-Dawley Tampons, Surgical* Time Factors Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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25655-41-8/Povidone-Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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