| A modified rabbit model of carotid atherosclerotic plaque suitable for the stroke study and MRI evaluation. | |
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MedLine Citation:
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PMID: 21793783 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract In order to induce a modified rabbit model of carotid atherosclerotic plaque which suitable for the stroke study and to evaluate the lesion with magnetic resonance imaging (MRI). 8 rabbits of group A were fed with high-fat diet only. Atherosclerosis at the right common carotid artery was induced in rabbits of group B (n = 12) by high-fat diet and balloon catheter injury to the endothelium four weeks later. The rabbits were examined in vivo with a 1.5-T MRI. After 4 weeks on the high-fat diet the serum lipid levels were markedly increased, which became significantly higher than the baseline levels. The lesions on both MRI and histology were remarkable. One week after balloon injury, the signal of injured right common carotid was higher on all the contrast-weighted images than the left side. The extent of abnormal signal was reduced nine week after balloon injury. Hemorrhage was detected on all the contrast-weighted images. In conclusion, the rabbit model established by the authors is such a feasible one to the study of stroke caused by carotid atherosclerosis. |
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Authors:
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Fei Wang; Tong Tong; Yi Feng Peng; Jing Li Tian; Wei Zhong Gu; Guang Yu Tang; Dao Ying Geng; Yingsheng Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-28 |
Journal Detail:
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Title: The International journal of neuroscience Volume: - ISSN: 1563-5279 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Radiology, Tenth People's Hospital, Tongji University , Shanghai 200072 , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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