Document Detail

A modified inflammatory bowel disease questionnaire and the Vaizey Incontinence questionnaire are more sensitive measures of acute gastrointestinal toxicity during pelvic radiotherapy than RTOG grading.
MedLine Citation:
PMID:  16580497     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Simple scales with greater sensitivity than Radiation Therapy Oncology Group (RTOG) grading to detect acute gastrointestinal toxicity during pelvic radiotherapy, could be clinically useful. METHODS AND MATERIALS: Do questionnaires used in benign gastrointestinal diseases detect toxicity in patients undergoing radiotherapy? The patient-completed Inflammatory Bowel Disease (IBDQ) and Vaizey Incontinence questionnaires were compared prospectively at baseline and at Week 5 to physician-completed RTOG grading. RESULTS: A total of 107 patients, median age 63 years, were recruited. After 5 weeks of treatment, patients with gynecologic and gastrointestinal cancer were more symptomatic than urologic patients (p = 0.012; p = 0.014). Overall, 94% had altered bowel habits, 80% loose stool, 74% frequency, 65% difficult gas, 60% pain, >48% distress, 44% tenesmus, >40% restrictions in daily activity, 39% urgency, 37% fecal incontinence, and 40% required antidiarrheal medication. The median RTOG score was 1 (range, 0-2), median IBDQ score 204.5 (range, 74-224), and median Vaizey score 5 (range, 0-20). Chemotherapy preceding radiotherapy increased fecal incontinence (p = 0.002). RTOG scores stabilized after 3 weeks, IBDQ scores peaked at Week 4, and Vaizey scores worsened throughout treatment. IBDQ and Vaizey scores distinguished between groups with different RTOG scores. CONCLUSION: The IBDQ and Vaizey questionnaires are reliable and sensitive, offering greater insight into the severity and range of symptoms compared with RTOG grading.
Usman Khalid; Camilla McGough; Claire Hackett; Peter Blake; Kevin J Harrington; Vincent S Khoo; Diana Tait; Andrew R Norman; H Jervoise N Andreyev
Related Documents :
10691817 - Oxybutynin for detrusor instability with adjuvant salivary stimulant pastilles to impro...
20707767 - Impact of solifenacin on diary-recorded and patient-reported urgency in patients with s...
6219577 - Effects of dichloromethylene diphosphonate in women with breast carcinoma metastatic to...
16412747 - A randomized comparative study of the effects of oral and topical estrogen therapy on t...
16275247 - Short-term effect of transdermal estrogen on autonomic nervous modulation in postmenopa...
24233127 - Increased brain amyloid deposition in patients with a lifetime history of major depress...
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  64     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-03     Completed Date:  2006-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1432-41     Citation Subset:  IM    
Department of Medicine, The Royal Marsden Hospital, London and Surrey, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Fecal Incontinence / etiology
Gastrointestinal Neoplasms / radiotherapy*
Gastrointestinal Tract / radiation effects*
Genital Neoplasms, Female / radiotherapy*
Inflammatory Bowel Diseases / etiology
Middle Aged
Prospective Studies
Quality of Life
Questionnaires / standards*
Radiation Oncology / standards
Sensitivity and Specificity
Urologic Neoplasms / radiotherapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Systematic evaluation of MRI findings in different stages of treatment of cervical cancer: potential...
Next Document:  Enhanced radiosensitization of p53 mutant cells by oleamide.