| A moderate intake of phytosterols from habitual diet affects cholesterol metabolism. | |
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MedLine Citation:
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PMID: 20358353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholesterol metabolism homeostasis is the result of a balance between synthesis, degradation and intestinal absorption. It is well established that intestinal cholesterol absorption efficiency can be modified by the intake of phytosterol-enriched food and, therefore, have a serum cholesterol-lowering effect. Recent epidemiological and clinical studies have shown that presence of phytosterols at normal diet levels could also be effective on lowering total and LDL serum cholesterol since they affect whole-body cholesterol metabolism even at those moderate doses. The aim of this study was to analyze the effect of the levels of the naturally-occurring phytosterols in the diet on cholesterol metabolism parameters. In order to do that a group of 99 healthy volunteers was studied for their dietary habits and surrogate markers of cholesterol synthesis and absorption. The mean daily dietary intake of phytosterols, measured by a food semiquantitative frequency questionnaire, was found to be 494 mg being beta-sitosterol the major contributor to it. Subjects were classified into tertiles according to their total phytosterol intake and comparisons were done between subgroups. No statistical differences were observed for surrogate markers of intestinal cholesterol absorption, but a significant increase in the cholesterol synthesis surrogate marker lathosterol-to-cholesterol ratio associated to highest dietary phytosterol intake was observed. Regardless of this, only a non significant trend toward a less atherogenic lipid profile was observed in the upper tertile. In conclusion, the intake of moderate amounts of phytosterols naturally present in habitual diet may affect cholesterol metabolism and specially the rate of cholesterol synthesis as estimated by the surrogate marker lathosterol-to-cholesterol ratio in serum. |
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Authors:
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T Sanclemente; I Marques-Lopes; M Faj?-Pascual; M Cof?n; E Jarauta; E Ros; J Puzo; A L Garc?a-Ot?n |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and biochemistry Volume: 65 ISSN: 1138-7548 ISO Abbreviation: J. Physiol. Biochem. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812509 Medline TA: J Physiol Biochem Country: Spain |
Other Details:
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Languages: eng Pagination: 397-404 Citation Subset: IM |
Affiliation:
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Facultad de Ciencias de la Salud y del Deporte, Universidad de Zaragoza, Huesca, Espa?a. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Aged Anthropometry Body Mass Index Cholesterol / blood*, metabolism* Diet* Female Homeostasis Humans Male Middle Aged Models, Biological Phytosterols / chemistry*, metabolism Sitosterols / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Phytosterols; 0/Sitosterols; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 80-99-9/lathosterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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