Document Detail


A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults.
MedLine Citation:
PMID:  22572647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nutrient stimulation of muscle protein anabolism is blunted with aging and may contribute to the development and progression of sarcopenia in older adults. This is likely due to insulin resistance of protein metabolism and/or endothelial dysfunction with a reduction in nutritive flow, both of which can be improved by aerobic exercise.
OBJECTIVE: Our objective was to determine whether increasing physical activity can enhance the muscle protein anabolic effect of essential amino acid (EAA) + sucrose intake in older subjects by improving nutritive flow and/or insulin signaling.
DESIGN: Using a randomized crossover design, we measured in older subjects [n = 6, 70 ± 3 y of age, BMI (in kg/m2) of 25 ± 1] the acute effects of increasing physical activity with aerobic exercise, as compared with normal sedentary lifestyle, on the response of blood flow, microvascular perfusion, insulin signaling, and muscle protein kinetics to EAA+sucrose intake.
RESULTS: No differences between treatment groups were found in the basal state. The change from the basal state in blood flow, muscle perfusion, phenylalanine delivery, net balance, and muscle protein synthesis during the consumption of EAA+sucrose was significantly higher after the exercise than after the control treatment (P < 0.05). Insulin signaling increased during EAA+sucrose ingestion in both groups (P < 0.05).
CONCLUSIONS: Our data indicate that a prior bout of aerobic exercise increases the anabolic effect of nutrient intake in older adults. This effect appears to be mediated by an exercise-induced improvement in nutrient-stimulated vasodilation and nutrient delivery to muscle rather than to improved insulin signaling. This trial was registered at clinicaltrials.gov as NCT00690534.
Authors:
Kyle L Timmerman; Shaheen Dhanani; Erin L Glynn; Christopher S Fry; Micah J Drummond; Kristofer Jennings; Blake B Rasmussen; Elena Volpi
Related Documents :
16871927 - Evaluation of nasal volume by acoustic rhinometry before and after physical exercise.
7498637 - Perception and reflex responses to intestinal distention in humans are modified by simu...
1605007 - Biochemical analysis of vocal fold polyps.
18355977 - Diffusion-weighted magnetic resonance imaging to evaluate major salivary gland function...
22766027 - Exercise with a twist: left ventricular twist and recoil in healthy young and middle-ag...
17151737 - Acceptance by stoats (mustela erminea) of 1080 (sodium monofluoroacetate) in small-volu...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-09
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  95     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-07-27     Revised Date:  2014-07-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1403-12     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00690534
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Amino Acids, Essential / metabolism*
Blood Circulation
Body Mass Index
Cross-Over Studies
Diet*
Dietary Sucrose / metabolism
Energy Intake
Energy Metabolism / physiology*
Exercise / physiology*
Exercise Therapy
Female
Humans
Insulin / metabolism
Male
Muscle Proteins / biosynthesis*
Muscle, Skeletal / blood supply,  metabolism*
Phenylalanine / metabolism
Sarcopenia / metabolism,  prevention & control*
Sedentary Lifestyle
Signal Transduction
Sucrose / metabolism
Grant Support
ID/Acronym/Agency:
P30 AG024832/AG/NIA NIH HHS; P30 AG024832/AG/NIA NIH HHS; R01 AG018311/AG/NIA NIH HHS; S10 RR16650/RR/NCRR NIH HHS; T32 HD07539/HD/NICHD NIH HHS; UL1 TR000071/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids, Essential; 0/Dietary Sucrose; 0/Insulin; 0/Muscle Proteins; 47E5O17Y3R/Phenylalanine; 57-50-1/Sucrose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lipoprotein subfractions and dietary intake of n-3 fatty acid: the Genetics of Coronary Artery Disea...
Next Document:  Childhood serum cholesterol ester fatty acids are associated with blood pressure 27 y later in the C...