| A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. | |
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MedLine Citation:
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PMID: 22572647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nutrient stimulation of muscle protein anabolism is blunted with aging and may contribute to the development and progression of sarcopenia in older adults. This is likely due to insulin resistance of protein metabolism and/or endothelial dysfunction with a reduction in nutritive flow, both of which can be improved by aerobic exercise. OBJECTIVE: Our objective was to determine whether increasing physical activity can enhance the muscle protein anabolic effect of essential amino acid (EAA) + sucrose intake in older subjects by improving nutritive flow and/or insulin signaling. DESIGN: Using a randomized crossover design, we measured in older subjects [n = 6, 70 ± 3 y of age, BMI (in kg/m2) of 25 ± 1] the acute effects of increasing physical activity with aerobic exercise, as compared with normal sedentary lifestyle, on the response of blood flow, microvascular perfusion, insulin signaling, and muscle protein kinetics to EAA+sucrose intake. RESULTS: No differences between treatment groups were found in the basal state. The change from the basal state in blood flow, muscle perfusion, phenylalanine delivery, net balance, and muscle protein synthesis during the consumption of EAA+sucrose was significantly higher after the exercise than after the control treatment (P < 0.05). Insulin signaling increased during EAA+sucrose ingestion in both groups (P < 0.05). CONCLUSIONS: Our data indicate that a prior bout of aerobic exercise increases the anabolic effect of nutrient intake in older adults. This effect appears to be mediated by an exercise-induced improvement in nutrient-stimulated vasodilation and nutrient delivery to muscle rather than to improved insulin signaling. This trial was registered at clinicaltrials.gov as NCT00690534. |
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Authors:
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Kyle L Timmerman; Shaheen Dhanani; Erin L Glynn; Christopher S Fry; Micah J Drummond; Kristofer Jennings; Blake B Rasmussen; Elena Volpi |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-05-09 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 95 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-21 Completed Date: 2012-07-27 Revised Date: 2013-01-30 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1403-12 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, TX, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00690534 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amino Acids, Essential / metabolism* Blood Circulation Body Mass Index Cross-Over Studies Diet* Dietary Sucrose / metabolism Energy Intake Energy Metabolism / physiology* Exercise / physiology* Exercise Therapy Female Humans Insulin / metabolism Male Muscle Proteins / biosynthesis* Muscle, Skeletal / blood supply, metabolism* Phenylalanine / metabolism Sarcopenia / metabolism, prevention & control* Sedentary Lifestyle Signal Transduction Sucrose / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P30 AG024832/AG/NIA NIH HHS; R01 AG018311/AG/NIA NIH HHS; S10 RR16650/RR/NCRR NIH HHS; T32 HD07539/HD/NICHD NIH HHS; UL1 TR000071/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Essential; 0/Dietary Sucrose; 0/Insulin; 0/Muscle Proteins; 57-50-1/Sucrose; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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