| A model of ventilation of the healthy human lung. | |
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MedLine Citation:
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PMID: 20655612 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This paper presents a model of the lung mechanics which simulates the pulmonary alveolar ventilation. The model includes aspects of: the alveolar geometry; pressure due to the chest wall; pressure due to surface tension determined by surfactant activity; pressure due to lung tissue elasticity; and pressure due to the hydrostatic effects of the lung tissue and blood. The cross-sectional area of the lungs in the supine position derived from computed tomography is used to construct a horizontally layered model, which simulates heterogeneous ventilation distribution from the non-dependent to the dependent layers of the lungs. The model is in agreement with experimentally measured hysteresis of the pressure-volume curve of the lungs, static lung compliance, changes in lung depth during breathing and density distributions at total lung capacity (TLC) and residual volume (RV). In the dependent layers of the lungs, alveolar collapse may occur at RV, depending on the assumptions concerning lung tissue elasticity at very low alveolar volumes. The model simulations showed that ventilation increased with depth in the lungs, although not as pronounced as observed experimentally. The model simulates alveolar ventilation including all of the mentioned components of the respiratory system and to be validated against all the above mentioned experimental data. |
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Authors:
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K L Steimle; M L Mogensen; D S Karbing; J Bernardino de la Serna; S Andreassen |
Publication Detail:
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Type: Journal Article Date: 2010-07-23 |
Journal Detail:
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Title: Computer methods and programs in biomedicine Volume: 101 ISSN: 1872-7565 ISO Abbreviation: Comput Methods Programs Biomed Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506513 Medline TA: Comput Methods Programs Biomed Country: Ireland |
Other Details:
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Languages: eng Pagination: 144-55 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Center for Model-Based Medical Decision Support, Aalborg University, Aalborg, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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