Document Detail


A model for ultrasound absorption and dispersion in dilute suspensions of nanometric contrast agents.
MedLine Citation:
PMID:  23231105     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ultrasound dispersion and absorption are examined in dilute suspensions of contrast agents of nanometric size, with a typical radius around 100 nm. These kinds of contrast agents are designed for targeted delivery of drugs for cancer treatment. Compared to standard contrast agents used for imaging, particles are of smaller size to pass through the endothelial barrier, their shell, made up of biocompatible polymer, is stiffer to undergo a longer lifetime, and they have a liquid core instead of a gaseous one. Ultrasound propagation in dilute suspension is modeled by combining two modes for particle oscillations. The first one is a dilatational mode assuming an incompressible shell with a rheological behavior of Kelvin-Voigt or Maxwell type. The second one is a translational mode induced by visco-inertial interaction with the ambient fluid. The relative importance of these two modes of interaction on both dispersion and absorption is quantified and analyzed for a model system and for two radii (75 and 150 nm) and the two rheological models. The influence of shell parameters (Young modulus, viscosity, and relative thickness) is finally discussed.
Authors:
François Coulouvrat; Jean-Louis Thomas; Ksenia Astafyeva; Nicolas Taulier; Jean-Marc Conoir; Wladimir Urbach
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  132     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  -    
Other Details:
Languages:  ENG     Pagination:  3748-3759     Citation Subset:  -    
Affiliation:
Université Pierre et Marie Curie-Paris 6, Institut Jean Le Rond d'Alembert, UMR CNRS 7190, 4 place Jussieu, 75252 Paris cedex 05, France.
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