Document Detail


A model of thalamocortical relay cells.
MedLine Citation:
PMID:  15613378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well established that the main intrinsic electrophysiological properties of thalamocortical relay cells, production of a low threshold burst upon release from hyperpolarized potential and production of a train of single spikes following stimulation from depolarized potentials, can be readily modelled using a single compartment. There is, however, another less well explored intrinsic electrophysiological characteristic of relay cells for which models have not yet accounted: at somatic potentials near spike threshold, relay cells produce a fast ragged high threshold oscillation in somatic voltage. Optical [Ca(2+)] imaging and pharmacological tests indicate that this oscillation correlates with a high threshold Ca(2+) current in the dendrites. Here we present the development of a new compartment model of the thalamic relay cell guided by the simultaneous constraints that it must produce the familiar regular spiking relay mode and low threshold rebound bursts which characterize these cells, as well as the less-studied fast oscillation occurring at near-threshold somatic potentials. We arrive at a model cell which is capable of the production of isolated high threshold Ca(2+) spikes in distal branch segments, driven by a rapidly inactivating intermediate threshold Ca(2+) channel. Further, the model produces the low threshold spike behaviour of the relay cell without requiring high T-current density in the distal dendritic segments. The results thus support a new picture of the dendritic tree of relay cells which may have implications for the manner in which thalamic relay cells integrate descending input from the cortex.
Authors:
Paul A Rhodes; Rodolfo Llinás
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Publication Detail:
Type:  Journal Article     Date:  2004-12-21
Journal Detail:
Title:  The Journal of physiology     Volume:  565     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2005-09-12     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  765-81     Citation Subset:  IM    
Affiliation:
Department of Physiology and Neuroscience, New York University Medical School, 550 1st Avenue, New York, NY 10016, USA. paul@rhodesholdings.net
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects,  physiology*
Anesthetics, Local / pharmacology
Animals
Cadmium / pharmacology
Calcium Channels, T-Type / physiology
Cerebral Cortex / cytology*
Dendrites / physiology
Humans
Models, Neurological*
Neural Pathways
Neurons / physiology*,  ultrastructure
Nickel / pharmacology
Periodicity
Tetrodotoxin / pharmacology
Thalamus / cytology*
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 0/Calcium Channels, T-Type; 4368-28-9/Tetrodotoxin; 7440-02-0/Nickel; 7440-43-9/Cadmium
Comments/Corrections

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