Document Detail

A model study of periodic breathing, stability of the neonatal respiratory system, and causes of sudden infant death syndrome.
MedLine Citation:
PMID:  9394903     Owner:  NLM     Status:  MEDLINE    
A mathematical model of the neonatal respiratory system has been modified and used to examine the system under various physiological conditions at different stages of maturity. The respiratory responses in hypoxia, periodic breathing and following a sign have been analyzed. The effects of different respiratory parameters on the stability of the system for normal and premature infants have been investigated. The causes of periodic breathing, apnea spells and sudden infant death syndrome for full-term and premature infants have been studied, and the results compared with the available experimental findings. The response of the infant respiratory system has been found to be highly sensitive to several parameters of the system, as indicated by the results of this study. These significant parameters are sensitivity factor of central receptors to carbon dioxide, sensitivity factor of arterial receptors to carbon dioxide, sensitivity factor of arterial receptors to oxygen, functional residual capacity of the lungs, the alveolar-arterial oxygen difference and the lungs shunt ratio. It has been shown that different parts of the respiratory controller have antagonistic effects on hypoxic periodic breathing and apnea of infancy.
F T Tehrani
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medical engineering & physics     Volume:  19     ISSN:  1350-4533     ISO Abbreviation:  Med Eng Phys     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-02     Completed Date:  1998-01-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-55     Citation Subset:  IM    
Department of Electrical Engineering, California State University, Fullerton 92831-3599, USA.
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MeSH Terms
Anoxia / physiopathology
Computer Simulation*
Infant, Newborn
Infant, Premature
Models, Biological*
Respiratory Mechanics
Respiratory Physiological Phenomena*
Sudden Infant Death / etiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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