Document Detail


A model of stress-induced geometrical remodeling of vessel segments adjacent to stents and artery/graft anastomoses.
MedLine Citation:
PMID:  10988028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mismatch between the elastic properties and initial geometry of a host artery and an implanted stent or graft cause significant stress concentration at the zones close to junctions. This may contribute to the often observed intimal hyperplasia, resulting in late lumen loss and eventual restenosis. This study proposes a mathematical model for stress-induced thickening of the arterial wall at the zones close to an implanted stent or graft. The host artery was considered initially as a cylindrical shell with constant thickness that was clamped to the stent or graft, which was assumed to be non-deformable in the circumferential direction. It was assumed that the abnormal circumferential and axial stresses due to the bending of the arterial wall cause wall thickening that tends to restore the stress state close to that existing far from the junction. The linear equations of a cylindrical shell with variable thickness were coupled to an evolution equation for the wall thickness. These equations were solved numerically and a parametric study was performed using finite difference method and explicit time step. The results show that the remodeling process is self-limiting and leads to local thickening that gradually decreases with distance from the edge of the stent/graft. Model predictions were tested against morphological findings existing in the literature. Recommendations on stent designs that reduce stress concentrations are discussed.
Authors:
A Rachev; E Manoach; J Berry; J E Moore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of theoretical biology     Volume:  206     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-19     Completed Date:  2000-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-43     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Bulgarian Academy of Sciences, Institute of Mechanics, Sofia, 1113, Bulgaria. rachev@bgcict.acad.bg
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MeSH Terms
Descriptor/Qualifier:
Anastomosis, Surgical*
Arteries
Constriction, Pathologic
Elasticity
Humans
Hyperplasia
Models, Cardiovascular*
Postoperative Period
Recurrence
Stents*
Stress, Mechanical
Tunica Intima / pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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