Document Detail

A model of stress-induced geometrical remodeling of vessel segments adjacent to stents and artery/graft anastomoses.
MedLine Citation:
PMID:  10988028     Owner:  NLM     Status:  MEDLINE    
The mismatch between the elastic properties and initial geometry of a host artery and an implanted stent or graft cause significant stress concentration at the zones close to junctions. This may contribute to the often observed intimal hyperplasia, resulting in late lumen loss and eventual restenosis. This study proposes a mathematical model for stress-induced thickening of the arterial wall at the zones close to an implanted stent or graft. The host artery was considered initially as a cylindrical shell with constant thickness that was clamped to the stent or graft, which was assumed to be non-deformable in the circumferential direction. It was assumed that the abnormal circumferential and axial stresses due to the bending of the arterial wall cause wall thickening that tends to restore the stress state close to that existing far from the junction. The linear equations of a cylindrical shell with variable thickness were coupled to an evolution equation for the wall thickness. These equations were solved numerically and a parametric study was performed using finite difference method and explicit time step. The results show that the remodeling process is self-limiting and leads to local thickening that gradually decreases with distance from the edge of the stent/graft. Model predictions were tested against morphological findings existing in the literature. Recommendations on stent designs that reduce stress concentrations are discussed.
A Rachev; E Manoach; J Berry; J E Moore
Related Documents :
9423218 - Histological changes in chronic experimental aneurysms surgically fashioned in sheep.
8827638 - Validity and reproducibility of color enhancement of b-mode ultrasound images of far wa...
7127698 - Sequence and timing of ventricular wall motion in patients with bundle branch block. as...
12960678 - Erk1/2-mediated vasoconstriction normalizes wall stress in small mesenteric arteries du...
21177298 - Rapidly growing aortic arch aneurysm in behcet's disease.
20850658 - The trans-subclavian retrograde approach for transcatheter aortic valve replacement: si...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of theoretical biology     Volume:  206     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-19     Completed Date:  2000-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-43     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Bulgarian Academy of Sciences, Institute of Mechanics, Sofia, 1113, Bulgaria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anastomosis, Surgical*
Constriction, Pathologic
Models, Cardiovascular*
Postoperative Period
Stress, Mechanical
Tunica Intima / pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  What does a common channel for electrolytes and non-electrolytes in the sperm mean?
Next Document:  The hypothesized hormonal control of offspring sex ratio: evidence from families ascertained by schi...