| A model for simulation and patient-specific visualization of the tissue volume of influence during brain microdialysis. | |
| | |
MedLine Citation:
|
PMID: 22081236 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Microdialysis can be used in parallel to deep brain stimulation (DBS) to relate biochemical changes to the clinical outcome. The aim of the study was to use the finite element method to predict the tissue volume of influence (TVI(max)) and its cross-sectional radius (r (TVImax)) when using brain microdialysis, and visualize the TVI(max) in relation to patient anatomy. An equation based on Fick's law was used to simulate the TVI(max). Factorial design and regression analysis were used to investigate the impact of the diffusion coefficient, tortuosity and loss rate on the r (TVImax). A calf brain tissue experiment was performed to further evaluate these parameters. The model was implemented with pre-(MRI) and post-(CT) operative patient images for simulation of the TVI(max) for four patients undergoing microdialysis in parallel to DBS. Using physiologically relevant parameter values, the r (TVImax) for analytes with a diffusion coefficient D = 7.5 × 10(-6) cm(2)/s was estimated to 0.85 ± 0.25 mm. The simulations showed agreement with experimental data. Due to an implanted gold thread, the catheter positions were visible in the post-operative images. The TVI(max) was visualized for each catheter. The biochemical changes could thereby be related to their anatomical origin, facilitating interpretation of results. |
| | |
Authors:
|
Elin Diczfalusy; Peter Zsigmond; Nil Dizdar; Anita Kullman; Dan Loyd; Karin Wårdell |
Related Documents
:
|
21987606 - Special diaphragm-like strictures of small bowel unrelated to non-steroidal anti-inflam... 21923236 - Association of magnetic resonance imaging signal changes and outcome prediction after s... 21566086 - Repeatability and reproducibility of landmarks--a three-dimensional computed tomography... 16391946 - 3-d imaging and quantitative comparison of human dentitions and simulated bite marks. 21194326 - Transcranial magnetic stimulation in doberman pinschers with clinically relevant and cl... 12623046 - Ct in the diagnosis of isolated cysticercal infestation of extraocular muscle. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-13 |
Journal Detail:
|
Title: Medical & biological engineering & computing Volume: - ISSN: 1741-0444 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7704869 Medline TA: Med Biol Eng Comput Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Biomedical Engineering, Linköping University, 581 85, Linköping, Sweden, elin.diczfalusy@liu.se. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Applied Patent RFID Systems for Building Reacting HEPA Air Ventilation System in Hospital Operation ...
Next Document: Gender Differences in Predicting Antisocial Behaviors: Developmental Consequences of Physical and Re...