Document Detail

A model of reflex tracheal constriction in the dog.
MedLine Citation:
PMID:  7437649     Owner:  NLM     Status:  MEDLINE    
1 A tracheal pouch with its nerve and blood supply intact has been prepared in situ in dogs. 2 Mechanical stimulation of the upper airways in dogs anaesthetized with chloralose induced a consistent increase in pouch pressure which was abolished by bilateral vagal section. 3 The response of the pouch following mechanical stimulation of the airways was abolished by intravenous pentobarbitone, atropine, administered systemically or when present in the pouch, and tetracaine, applied to the stimulus area or when present in the pouch. 4 Salbutamol had no inhibitory effects on the response regardless of its route of administration. 5 These results suggest that the increase in pouch pressure following mechanical stimulation of the upper airways is mediated by a vagal reflex arc. 6 The technique may distinguish between drugs the site of action of which is at the afferent or efferent end of this reflex arc.
C P Allott; D P Evans; B E Loveday; P W Marshall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  70     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-02-24     Completed Date:  1981-02-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  IM    
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MeSH Terms
Airway Resistance / drug effects*
Albuterol / pharmacology
Atropine / pharmacology
Chloralose / pharmacology
Muscle Contraction / drug effects
Pentobarbital / pharmacology
Reflex / drug effects*
Tetracaine / pharmacology
Trachea / drug effects
Reg. No./Substance:
15879-93-3/Chloralose; 18559-94-9/Albuterol; 51-55-8/Atropine; 76-74-4/Pentobarbital; 94-24-6/Tetracaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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