Document Detail


A model for the radionuclide measurement of ascitic fluid volumes.
MedLine Citation:
PMID:  722324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Technetium-99m phytate colloids formed in vitro and in vivo were examined as radioindicators for estimation of the volume of third-space fluid in an ovarian ascites model using C3HeB/FeJ mice. In double-label experiments, the accuracy of the colloids for dilution analysis was found to be equal or superior to that of I-125 HSA. Sampling times 3--5 min after intraperitoneal administration were found to produce the best volume estimates. Four needle-stopcock assemblies inserted sequentially into the quadrants of the peritoneal cavity were used for administration and sampling of the radioindicators. The stopcocks could be closed to prevent leakage of ascitic fluid during the procedure. In contrast to radiolabeled albumin, Tc-99m phytate colloids have clinical use for simultaneous imaging of radiotracer migration to assess potential occlusion of diaphragmatic lymphatics by neoplastic cells, and for dilution analysis to estimate volume of ascitic fluid.
Authors:
W D Kaplan; M A Davis; R F Uren; T Wisotsky; M LaTegola
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  19     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-02-26     Completed Date:  1979-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1138-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Ascites / radionuclide imaging
Ascitic Fluid / physiology*
Disease Models, Animal
Female
Mice
Mice, Inbred C3H
Neoplasms, Experimental / pathology
Ovarian Neoplasms / pathology
Radionuclide Imaging*
Technetium / diagnostic use*
Chemical
Reg. No./Substance:
7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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