Document Detail

A model of osteon closure in cortical bone.
MedLine Citation:
PMID:  2257518     Owner:  NLM     Status:  MEDLINE    
A model of osteon closure is presented that incorporates some physiologic features of cortical bone remodeling, such as matrix synthesizing activity of osteoblasts, their burial as osteocytes, and elimination of cells. A simplified version of the model assumes a constant osteoblast activity throughout radial closure. An extended version allows for variable osteoblasts activity and is based on Lee's law of radial closure kinetics. The model calculations (extended model) show that both in humans and beagle dogs osteoblast activity steadily decreases during radial closure of the osteon. The potential of the model is also illustrated by calculating the dynamic change of the geometrical shape of the closing cone and the time dependence of the osteoid seam width, number of osteoblasts and bone formation rate in the closing cone.
E Polig; W S Jee
Related Documents :
11091948 - Epicardial suction: a new approach to mechanical testing of the passive ventricular wall.
22986078 - Class-specific weighting for markov random field estimation: application to medical ima...
24555668 - Evaluation of copy number variation detection for a snp array platform.
18447088 - Prediction of work efficiency in early adolescence under the effects of noise.
22879758 - Suicide note sentiment classification: a supervised approach augmented by web data.
22270248 - Cervical neural space narrowing during simulated rear crashes with anti-whiplash systems.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Calcified tissue international     Volume:  47     ISSN:  0171-967X     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-9     Citation Subset:  IM; S    
Institut für Genetik und für Toxikologie von Spaltstoffen, Kernforschungszentrum Karlsruhe, Federal Republic of Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Resorption / pathology,  physiopathology
Bone and Bones / anatomy & histology,  physiology*
Models, Biological*
Osteoblasts / cytology,  physiology
Osteogenesis / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Radiation-induced malignant pleural mesothelioma.
Next Document:  Bone death in hip fracture in the elderly.