Document Detail


A model of osteon closure in cortical bone.
MedLine Citation:
PMID:  2257518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model of osteon closure is presented that incorporates some physiologic features of cortical bone remodeling, such as matrix synthesizing activity of osteoblasts, their burial as osteocytes, and elimination of cells. A simplified version of the model assumes a constant osteoblast activity throughout radial closure. An extended version allows for variable osteoblasts activity and is based on Lee's law of radial closure kinetics. The model calculations (extended model) show that both in humans and beagle dogs osteoblast activity steadily decreases during radial closure of the osteon. The potential of the model is also illustrated by calculating the dynamic change of the geometrical shape of the closing cone and the time dependence of the osteoid seam width, number of osteoblasts and bone formation rate in the closing cone.
Authors:
E Polig; W S Jee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Calcified tissue international     Volume:  47     ISSN:  0171-967X     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-9     Citation Subset:  IM; S    
Affiliation:
Institut für Genetik und für Toxikologie von Spaltstoffen, Kernforschungszentrum Karlsruhe, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Resorption / pathology,  physiopathology
Bone and Bones / anatomy & histology,  physiology*
Dogs
Humans
Models, Biological*
Osteoblasts / cytology,  physiology
Osteogenesis / physiology*
Grant Support
ID/Acronym/Agency:
AR-38346/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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